Prediction of Clearance of Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins in Youngsters: Software of Allometric Scaling
There have been 13 monoclonal antibodies, seven polyclonal antibodies, and 9 therapeutic proteins (non-antibodies) within the examine. The clearance of therapeutic proteins was predicted utilizing the age dependent exponents (ADE) mannequin after which in contrast with the noticed clearance values.
There have been in whole 29 therapeutic proteins on this examine with 75 observations. The variety of observations with ≤30%, ≤50%, and >50% prediction error was 60 (80%), 72 (96%), and be 3 (4%), respectively. Total, the anticipated clearance values of therapeutic proteins in kids was good.
The allometric methodology proposed on this manuscript can be utilized to pick out first-in-pediatric dose of therapeutic proteins in pediatric medical trials.
A preliminary analysis of a regionally produced biotinylated polyclonal anti-rabies antibody for direct fast immunohistochemical take a look at (DRIT) within the Philippines
Subsequently, a biotinylated polyclonal antibody (pAb) towards the rabies lyssavirus (RABV) nucleoprotein was developed utilizing a plasmid cDNA vaccine derived from a problem virus commonplace 11 pressure. A preliminary analysis on the efficacy of this reagent in recognizing the Philippine RABV pressure was examined utilizing banked canine hippocampal tissue samples with DRIT and the outcomes had been in comparison with dFAT.
The consequences of acetone and formalin fixation on DRIT had been additionally assessed by way of immunoreactivity scores of the specimens. Of the 142 samples examined, 104 examined optimistic and 38 destructive utilizing each dFAT and DRIT, displaying 100% settlement between the 2 diagnostic procedures. Furthermore, no false optimistic or false destructive outcomes had been noticed utilizing acetone and formalin fixation.
Thus, regionally ready biotinylated pAb from plasmid cDNA can be utilized for DRIT, particularly in resource-limited laboratories within the Philippines. Nonetheless, these outcomes ought to be confirmed with a extra thorough analysis of this system, and the vary of detection must be additional evaluated in a bigger panel of animal samples and on different lyssav viruses.
PIBF1 Antibody |
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DF7171 | Affbiotech | 200ul | EUR 420 |
PIBF1 Antibody |
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DF7171-100ul | Affinity Biosciences | 100ul | EUR 280 |
PIBF1 Antibody |
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DF7171-200ul | Affinity Biosciences | 200ul | EUR 350 |
PIBF1 antibody |
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E39-06433 | EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
PIBF1 Antibody |
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E93072 | EnoGene | 100ul | EUR 255 |
Description: Available in various conjugation types. |
PIBF1 antibody |
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70R-19279 | Fitzgerald | 50 ul | EUR 289 |
Description: Rabbit polyclonal PIBF1 antibody |
PIBF1 Antibody |
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7237-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell. |
PIBF1 Antibody |
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7237-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell. |
PIBF1 antibody |
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70R-9148 | Fitzgerald | 50 ug | EUR 467 |
Description: Affinity purified rabbit polyclonal PIBF1 antibody |
PIBF1 Antibody |
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ABD7171 | Nova Lifetech | 100ug | EUR 325 |
PIBF1 Antibody |
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GWB-MS489C | GenWay Biotech | 50ug | Ask for price |
PIBF1 Antibody |
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MBS7136337-005mL | MyBiosource | 0.05mL | EUR 190 |
PIBF1 Antibody |
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MBS7136337-01mL | MyBiosource | 0.1mL | EUR 270 |
PIBF1 Antibody |
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MBS7136337-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
PIBF1 Antibody |
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MBS7127635-005mL | MyBiosource | 0.05mL | EUR 190 |
PIBF1 Antibody |
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MBS7127635-01mL | MyBiosource | 0.1mL | EUR 270 |
PIBF1 Antibody |
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MBS7127635-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
PIBF1 Antibody |
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MBS7127636-005mL | MyBiosource | 0.05mL | EUR 190 |
PIBF1 Antibody |
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MBS7127636-01mL | MyBiosource | 0.1mL | EUR 270 |
PIBF1 Antibody |
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MBS7127636-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
PIBF1 Antibody |
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MBS9410192-01mL | MyBiosource | 0.1mL | EUR 305 |
PIBF1 Antibody |
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MBS9410192-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
PIBF1 Antibody |
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MBS8505664-01mL | MyBiosource | 0.1mL | EUR 325 |
PIBF1 Antibody |
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MBS8505664-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
PIBF1 Antibody |
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MBS8505664-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
PIBF1 Antibody |
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MBS8505664-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
PIBF1 Antibody |
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MBS8505664-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
PIBF1 Antibody |
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MBS8516613-01mg | MyBiosource | 0.1mg | EUR 305 |
PIBF1 Antibody |
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MBS8516613-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
PIBF1 Antibody |
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MBS8516613-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
PIBF1 Antibody |
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MBS8516613-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
PIBF1 Antibody |
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MBS8516613-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
PIBF1 Antibody |
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MBS153429-01mg | MyBiosource | 0.1mg | EUR 445 |
PIBF1 Antibody |
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MBS153429-5x01mg | MyBiosource | 5x0.1mg | EUR 1965 |
PIBF1 Antibody |
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MBS9607820-01mL | MyBiosource | 0.1mL | EUR 260 |
PIBF1 Antibody |
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MBS9607820-02mL | MyBiosource | 0.2mL | EUR 305 |
PIBF1 Antibody |
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MBS9607820-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
Polyclonal PIBF1 Antibody |
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APR06805G | Leading Biology | 0.1 mg | EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PIBF1 . This antibody is tested and proven to work in the following applications: |
PIBF1 Polyclonal Antibody |
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E912033 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
PIBF1 Conjugated Antibody |
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C38564 | SAB | 100ul | EUR 476.4 |
PIBF1 Conjugated Antibody |
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C31261 | SAB | 100ul | EUR 476.4 |
PIBF1 Polyclonal Antibody |
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E-AB-12621-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-12621-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-12621-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-12621-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-19632-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-19632-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-19632-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-19632-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-17742-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-17742-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-17742-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-17742-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-15826-120uL | Elabscience Biotech | 120uL | EUR 240 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-15826-200uL | Elabscience Biotech | 200uL | EUR 399 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-15826-20uL | Elabscience Biotech | 20uL | EUR 73 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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E-AB-15826-60uL | Elabscience Biotech | 60uL | EUR 143 |
Description: Unconjugated |
PIBF1 Polyclonal Antibody |
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MBS127548-002mL | MyBiosource | 0.02mL | EUR 200 |
PIBF1 Polyclonal Antibody |
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MBS127548-005mL | MyBiosource | 0.05mL | EUR 255 |
PIBF1 Polyclonal Antibody |
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MBS127548-01mL | MyBiosource | 0.1mL | EUR 345 |
PIBF1 Polyclonal Antibody |
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MBS127548-02mL | MyBiosource | 0.2mL | EUR 545 |
PIBF1 Polyclonal Antibody |
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MBS127548-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
PIBF1 Polyclonal Antibody |
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MBS9131953-002mL | MyBiosource | 0.02mL | EUR 200 |
PIBF1 Polyclonal Antibody |
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MBS9131953-005mL | MyBiosource | 0.05mL | EUR 255 |
PIBF1 Polyclonal Antibody |
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MBS9131953-01mL | MyBiosource | 0.1mL | EUR 345 |
PIBF1 Polyclonal Antibody |
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MBS9131953-02mL | MyBiosource | 0.2mL | EUR 545 |
PIBF1 Polyclonal Antibody |
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MBS9131953-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
PIBF1 Polyclonal Antibody |
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MBS8567067-01mL | MyBiosource | 0.1mL | EUR 305 |
PIBF1 Polyclonal Antibody |
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MBS8567067-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
PIBF1 Polyclonal Antibody |
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MBS8567067-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
PIBF1 Polyclonal Antibody |
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MBS8567067-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
PIBF1 Polyclonal Antibody |
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MBS8567067-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
PIBF1 Polyclonal Antibody |
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MBS2561521-002mL | MyBiosource | 0.02mL | EUR 135 |
PIBF1 Polyclonal Antibody |
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MBS2561521-006mL | MyBiosource | 0.06mL | EUR 190 |
Acetylcholinesterase (AChE) polyclonal antibody from hybrid catfish (C. macrocephalus × C. gariepinus): Specification, sensitivity and cross reactivity
After that, the fish mind was dissected, AChE was extracted and purified by hydroxyapatite column chromatography and eluted with 0.2 M potassium phosphate buffer pH 6.8. This protocol gave 70% yield. Then, the mind extract was characterised utilizing 10% SDS-PAGE and Western blot probed with industrial polyclonal antibody particular to AChE (PAb-AChE). The protein, 71 kDa, was then used as an antigen to immunize mice for antibody manufacturing.
The polyclonal antibody (PAb) was characterised utilizing dot blot, Western blot and immunohistochemistry for immunolocalization of AChE in hybrid catfish uncovered to glyphosate. We discovered that the suitable dilution of antibody for each dot blot and Western blot was 1:3500, and 1:2500 for immunohistochemistry.
Cross reactivity testing confirmed that PAb-AChE can be utilized with AChE from striped snakehead fish on the similar dilution as used with AChE from hybrid catfish. It was concluded that PAb particular to hybrid catfish AChE from this work was extremely particular and delicate, and may cross-react with striped snakehead fish AChE. Thus, this polyclonal antibody could also be utilized in monitoring glyphosate publicity in hybrid catfish and striped snakehead fish.
ApoB antibody |
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10R-11069 | Fitzgerald | 100 ug | EUR 344 |
Description: Mouse monoclonal ApoB antibody |
ApoB antibody |
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20-1008 | Fitzgerald | 1 liter | Ask for price |
Description: Goat polyclonal ApoB antibody (Nephelometric and Turbidimetric grade) |
ApoB antibody |
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20-AG40 | Fitzgerald | 1 L | Ask for price |
Description: Goat polyclonal ApoB antibody |
ApoB antibody |
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20-AG40S | Fitzgerald | 5 ml | EUR 110 |
Description: Goat polyclonal ApoB antibody |
ApoB antibody |
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20-S1151G000-V0 | Fitzgerald | 10 ml | EUR 95 |
Description: Goat polyclonal Human ApoB antibody |
ApoB antibody |
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20C-CR2009GP | Fitzgerald | 1 mg | EUR 125 |
Description: Goat polyclonal ApoB antibody (IgG Fraction) |
ApoB antibody |
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20C-CR2009RP | Fitzgerald | 1 mg | EUR 125 |
Description: Rabbit polyclonal ApoB antibody |
ApoB antibody |
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20C-CR2009SP | Fitzgerald | 1 ml | EUR 370 |
Description: Sheep polyclonal ApoB antibody (Purified IgG) |
ApoB antibody |
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20R-1695 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Goat polyclonal ApoB antibody |
APOB Antibody |
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36751 | SAB | 100ul | EUR 319 |
APOB Antibody |
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36751-100ul | SAB | 100ul | EUR 302.4 |
APOB Antibody |
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1-CSB-PA780260 | Cusabio |
|
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Description: A polyclonal antibody against APOB. Recognizes APOB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:15-1:50 |
APOB Antibody |
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E036751 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
ApoB Antibody |
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E10-30214 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
APOB Antibody |
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DF12533 | Affbiotech | 200ul | EUR 420 |
APOB Antibody |
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DF12533-100ul | Affinity Biosciences | 100ul | EUR 280 |
APOB Antibody |
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DF12533-200ul | Affinity Biosciences | 200ul | EUR 350 |
ApoB Antibody |
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BF0278-100ul | Affinity Biosciences | 100ul | EUR 350 |
ApoB Antibody |
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BF0278-200ul | Affinity Biosciences | 200ul | EUR 450 |
ApoB Antibody |
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BF0278-50ul | Affinity Biosciences | 50ul | EUR 250 |
APOB antibody |
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70R-15771 | Fitzgerald | 50 ul | EUR 285 |
Description: Rabbit polyclonal APOB antibody |
ApoB antibody |
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70C-CR2009GAP | Fitzgerald | 1 mg | EUR 363 |
Description: Affinity purified Goat polyclonal ApoB antibody |
ApoB antibody |
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70-XG15 | Fitzgerald | 1 G | Ask for price |
Description: Affinity purified Goat polyclonal ApoB antibody |
ApoB antibody |
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70R-7483 | Fitzgerald | 50 ug | EUR 467 |
Description: Rabbit polyclonal ApoB antibody raised against the middle region of APOB |
APOB Antibody |
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1-CSB-PA318254 | Cusabio |
|
|
Description: A polyclonal antibody against APOB. Recognizes APOB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:15-1:50 |
APOB Antibody |
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1-CSB-PA001918GA01HU | Cusabio |
|
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Description: A polyclonal antibody against APOB. Recognizes APOB from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
APOB Antibody |
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1-CSB-PA001918LA01HU | Cusabio |
|
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Description: A polyclonal antibody against APOB. Recognizes APOB from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
APOB Antibody |
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GWB-MN926H | GenWay Biotech | 50ug | Ask for price |
APOB Antibody |
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R36144-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Apolipoprotein B |
APOB Antibody |
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R32510 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. |
ApoB antibody |
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BF0278 | Nova Lifetech | 100ug | EUR 355 |
APOB Antibody |
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MBS7126852-005mL | MyBiosource | 0.05mL | EUR 190 |
APOB Antibody |
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MBS7126852-01mL | MyBiosource | 0.1mL | EUR 270 |
APOB Antibody |
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MBS7126852-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
APOB Antibody |
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MBS7126853-005mL | MyBiosource | 0.05mL | EUR 190 |
APOB Antibody |
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MBS7126853-01mL | MyBiosource | 0.1mL | EUR 270 |
APOB Antibody |
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MBS7126853-5x01mL | MyBiosource | 5x0.1mL | EUR 1205 |
APOB Antibody |
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MBS9413971-01mL | MyBiosource | 0.1mL | EUR 305 |
APOB Antibody |
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MBS9413971-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
ApoB antibody |
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MBS832088-10mL | MyBiosource | 10mL | EUR 200 |
ApoB antibody |
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MBS832088-5x10mL | MyBiosource | 5x10mL | EUR 740 |
ApoB antibody |
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MBS833633-5mL | MyBiosource | 5mL | EUR 215 |
ApoB antibody |
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MBS833633-5x5mL | MyBiosource | 5x5mL | EUR 820 |
ApoB Antibody |
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MBS850799-01mg | MyBiosource | 0.1mg | EUR 305 |
ApoB Antibody |
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MBS850799-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
ApoB Antibody |
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MBS850799-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
ApoB Antibody |
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MBS850799-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
ApoB Antibody |
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MBS850799-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
APOB Antibody |
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MBS1495245-005mg | MyBiosource | 0.05mg | EUR 190 |
APOB Antibody |
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MBS1495245-01mg | MyBiosource | 0.1mg | EUR 270 |
APOB Antibody |
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MBS1495245-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
ApoB antibody |
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MBS531858-1mg | MyBiosource | 1mg | EUR 370 |
ApoB antibody |
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MBS531858-5x1mg | MyBiosource | 5x1mg | EUR 1515 |
ApoB antibody |
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MBS531151-1mg | MyBiosource | 1mg | EUR 255 |
ApoB antibody |
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MBS531151-5x1mg | MyBiosource | 5x1mg | EUR 990 |
ApoB antibody |
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MBS530791-1mg | MyBiosource | 1mg | EUR 255 |
ApoB antibody |
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MBS530791-5x1mg | MyBiosource | 5x1mg | EUR 990 |
ApoB antibody |
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MBS534826-1mg | MyBiosource | 1mg | EUR 650 |
ApoB antibody |
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MBS534826-5x1mg | MyBiosource | 5x1mg | EUR 2780 |
ApoB antibody |
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MBS535357-INQUIRE | MyBiosource | INQUIRE | Ask for price |
ApoB antibody |
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MBS535719-1mL | MyBiosource | 1mL | EUR 610 |
ApoB antibody |
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MBS535719-5x1mL | MyBiosource | 5x1mL | EUR 2595 |
ApoB antibody |
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MBS531397-1mg | MyBiosource | 1mg | EUR 255 |
ApoB antibody |
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MBS531397-5x1mg | MyBiosource | 5x1mg | EUR 990 |
APOB Antibody |
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MBS5313164-005mL | MyBiosource | 0.05mL | EUR 485 |
APOB Antibody |
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MBS5313164-5x05mL | MyBiosource | 5x0.5mL | EUR 2045 |
ApoB antibody |
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MBS531324-1mg | MyBiosource | 1mg | EUR 370 |
ApoB antibody |
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MBS531324-5x1mg | MyBiosource | 5x1mg | EUR 1515 |
ApoB Antibody |
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MBS9602520-005mL | MyBiosource | 0.05mL | EUR 260 |
ApoB Antibody |
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MBS9602520-01mL | MyBiosource | 0.1mL | EUR 325 |
ApoB Antibody |
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MBS9602520-02mL | MyBiosource | 0.2mL | EUR 400 |
ApoB Antibody |
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MBS9602520-5x02mL | MyBiosource | 5x0.2mL | EUR 1750 |
APOB Antibody |
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MBS9611285-01mL | MyBiosource | 0.1mL | EUR 260 |
APOB Antibody |
|||
MBS9611285-02mL | MyBiosource | 0.2mL | EUR 305 |
APOB Antibody |
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MBS9611285-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
Apolipoprotein B (ApoB), anti-Human Polyclonal Antibody |
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MBS170645-10mg | MyBiosource | 10mg | EUR 1065 |
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