Complete exome sequencing reveals the maintained polyclonal nature from major to metastatic malignant peripheral nerve sheath tumor in two sufferers with NF1
Background: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive mushy tissue sarcomas with excessive metastatic charges and poor general affected person survival. There are at the moment no efficient therapies, underscoring the urgent have to outline the molecular etiologies that underlie MPNST development. The goal of this examine was to look at clonal development and establish the molecular occasions essential for MPNST unfold.
Strategies: In two sufferers with temporally and spatially distinct metastatic lesions, we employed complete exome sequencing (WES) to elucidate the genetic occasions of clonal development, thus figuring out the molecular occasions essential for MPNST unfold.
Outcomes: First, we demonstrated shared clonal origins for the metastatic lesions relative to the first tumors, which have been maintained all through the course of MPNST development, supporting the conclusion that most cancers cells with metastatic potential exist already within the major neoplasm.
Second, we found TRIM23, a member of the Tripartite Motif household of proteins, as a regulator of MPNST lung metastatic unfold in vivo.
Conclusions: The power to trace the genomic evolution from major to metastatic MPNST gives new insights into the sequence of genetic occasions required for tumor development and has recognized TRIM23 as a novel goal for future examine on this uncommon most cancers.
Key phrases: Genomics; MPNST; Metastasis; NF1; TRIM23
Acetylcholinesterase (AChE) polyclonal antibody from hybrid catfish (C. macrocephalus × C. gariepinus): Specification, sensitivity and cross reactivity
- AChE (acetylcholinesterase) is usually categorised as a selected biomarker of pesticide publicity. The goal of this examine was to supply AChE polyclonal antibody from hybrid catfish that have been uncovered to industrial glyphosate.
- The hybrid catfish was uncovered to glyphosate (0.75 mL/L) for 24 h. After that, the fish mind was dissected, AChE was extracted and purified by hydroxyapatite column chromatography and eluted with 0.2 M potassium phosphate buffer pH 6.8.
- This protocol gave 70% yield. Then, the mind extract was characterised utilizing 10% SDS-PAGE and Western blot probed with industrial polyclonal antibody particular to AChE (PAb-AChE). The protein, 71 kDa, was then used as an antigen to immunize mice for antibody manufacturing.
- The polyclonal antibody (PAb) was characterised utilizing dot blot, Western blot and immunohistochemistry for immunolocalization of AChE in hybrid catfish uncovered to glyphosate. We discovered that the suitable dilution of antibody for each dot blot and Western blot was 1:3500, and 1:2500 for immunohistochemistry.
- Cross reactivity testing confirmed that PAb-AChE can be utilized with AChE from striped snakehead fish on the identical dilution as used with AChE from hybrid catfish. It was concluded that PAb particular to hybrid catfish AChE from this work was extremely particular and delicate, and might cross-react with striped snakehead fish AChE.
- Thus, this polyclonal antibody could also be utilized in monitoring glyphosate publicity in hybrid catfish and striped snakehead fish.
Key phrases: Acetylcholinesterase (AChE); Biomarker; Glyphosate; Hybrid catfish; Polyclonal antibody (PAb).
Glutaredoxin 3 (GLRX3) Antibody (Biotin) |
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| 20-abx272401 | Abbexa |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human) |
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| 4-PAG979Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3) |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human) |
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| 4-PAG979Hu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3) |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse) |
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| 4-PAG979Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3) |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human) |
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| 4-MAG979Hu21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3) |
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Human Glutaredoxin-3 (GLRX3) |
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| 1-CSB-EP009523HU | Cusabio |
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Description: Recombinant Human Glutaredoxin-3(GLRX3) expressed in E.coli |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), PE |
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| 4-PAG979Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with PE. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), PE |
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| 4-PAG979Hu02-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with PE. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), PE |
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| 4-PAG979Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with PE. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), PE |
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| 4-MAG979Hu21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with PE. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), APC |
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| 4-PAG979Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with APC. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), Cy3 |
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| 4-PAG979Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with Cy3. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), HRP |
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| 4-PAG979Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with HRP. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), APC |
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| 4-PAG979Hu02-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with APC. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), Cy3 |
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| 4-PAG979Hu02-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with Cy3. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), HRP |
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| 4-PAG979Hu02-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with HRP. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), APC |
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| 4-PAG979Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with APC. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), Cy3 |
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| 4-PAG979Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with Cy3. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), HRP |
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| 4-PAG979Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with HRP. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), APC |
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| 4-MAG979Hu21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with APC. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), Cy3 |
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| 4-MAG979Hu21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with Cy3. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), HRP |
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| 4-MAG979Hu21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with HRP. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), FITC |
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| 4-PAG979Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with FITC. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), FITC |
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| 4-PAG979Hu02-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with FITC. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), FITC |
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| 4-PAG979Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with FITC. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), FITC |
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| 4-MAG979Hu21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with FITC. |
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Recombinant Glutaredoxin 3 (GLRX3) |
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| 4-RPG979Hu01 | Cloud-Clone |
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Description: Recombinant Human Glutaredoxin 3 expressed in: E.coli |
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Recombinant Glutaredoxin 3 (GLRX3) |
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| 4-RPG979Hu02 | Cloud-Clone |
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Description: Recombinant Human Glutaredoxin 3 expressed in: E.coli |
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Recombinant Glutaredoxin 3 (GLRX3) |
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| 4-RPG979Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Glutaredoxin 3 expressed in: E.coli |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-PAG979Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with APC-Cy7. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-PAG979Hu02-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with APC-Cy7. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), APC-Cy7 |
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| 4-PAG979Mu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with APC-Cy7. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-MAG979Hu21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with APC-Cy7. |
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Mouse Glutaredoxin 3 (GLRX3) Protein |
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| 20-abx167217 | Abbexa |
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Human Glutaredoxin 3 (GLRX3) Protein |
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| 20-abx066825 | Abbexa |
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Human Glutaredoxin 3 (GLRX3) Protein |
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| 20-abx066826 | Abbexa |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), Biotinylated |
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| 4-PAG979Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with Biotin. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Human), Biotinylated |
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| 4-PAG979Hu02-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with Biotin. |
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Glutaredoxin 3 (GLRX3) Polyclonal Antibody (Mouse), Biotinylated |
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| 4-PAG979Mu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glutaredoxin 3 (GLRX3). This antibody is labeled with Biotin. |
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Glutaredoxin 3 (GLRX3) Monoclonal Antibody (Human), Biotinylated |
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| 4-MAG979Hu21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Glutaredoxin 3 (GLRX3). This antibody is labeled with Biotin. |
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Cow Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx513140-96tests | Abbexa | 96 tests | EUR 1093.2 |
Rat Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx513143-96tests | Abbexa | 96 tests | EUR 801.6 |
Rat Glutaredoxin 3 (GLRX3) ELISA Kit |
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| 20-abx585294 | Abbexa |
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Pig Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx360481-96tests | Abbexa | 96 tests | EUR 990 |
Human Glutaredoxin 3 (GLRX3) CLIA Kit |
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| abx195696-96tests | Abbexa | 96 tests | EUR 990 |
Human Glutaredoxin 3 (GLRX3) CLIA Kit |
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| 20-abx495343 | Abbexa |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| 20-abx151684 | Abbexa |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx253888-96tests | Abbexa | 96 tests | EUR 848.4 |
Human Glutaredoxin 3 (GLRX3)ELISA Kit |
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| 201-12-2717 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Mouse Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx513142-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx570899-96tests | Abbexa | 96 tests | EUR 848.4 |
Mouse Glutaredoxin 3 (GLRX3) ELISA Kit |
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| 20-abx585293 | Abbexa |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| DLR-GLRX3-Hu-48T | DL Develop | 48T | EUR 620.4 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Glutaredoxin 3 (GLRX3) in samples from plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| DLR-GLRX3-Hu-96T | DL Develop | 96T | EUR 807.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Glutaredoxin 3 (GLRX3) in samples from plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| SEG979Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5677.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutaredoxin 3 (GLRX3) in plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| SEG979Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 572.76 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutaredoxin 3 (GLRX3) in plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| SEG979Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 766.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutaredoxin 3 (GLRX3) in plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| SEG979Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3090.6 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutaredoxin 3 (GLRX3) in plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| 4-SEG979Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Glutaredoxin 3 (GLRX3) in samples from plasma with no significant corss-reactivity with analogues from other species. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RDR-GLRX3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 652.8 |
Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RDR-GLRX3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 907.2 |
Human Glutaredoxin 3(GLRX3)ELISA Kit |
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| QY-E03319 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RD-GLRX3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 625.2 |
Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RD-GLRX3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 867.6 |
Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RD-GLRX3-Hu-48T | Reddot Biotech | 48T | EUR 452.7 |
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Description: plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RD-GLRX3-Hu-96T | Reddot Biotech | 96T | EUR 646.7 |
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Description: plasma. |
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Human Glutaredoxin 3 (GLRX3)ELISA Kit |
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| YLA3355HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Glutaredoxin 3 (GLRX3)ELISA Kit |
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| YLA3355HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RDR-GLRX3-Hu-48T | Reddot Biotech | 48T | EUR 475.34 |
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Description: plasma. |
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Human Glutaredoxin 3 (GLRX3) ELISA Kit |
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| RDR-GLRX3-Hu-96T | Reddot Biotech | 96T | EUR 679.04 |
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Description: plasma. |
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Monkey Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx358686-96tests | Abbexa | 96 tests | EUR 990 |
Rabbit Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx363618-96tests | Abbexa | 96 tests | EUR 990 |
Chicken Glutaredoxin 3 (GLRX3) ELISA Kit |
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| abx355772-96tests | Abbexa | 96 tests | EUR 990 |
A Polyclonal Immune Operate Assay Permits Dose-Dependent Characterization of Immunosuppressive Drug Results however Has Restricted Scientific Utility for Predicting An infection on an Particular person Foundation
Dosage of immunosuppressive medicine after transplantation critically determines rejection and an infection episodes. On this examine, a worldwide immune perform assay was characterised amongst controls, dialysis-patients, and transplant-recipients to judge its utility for pharmacodynamic monitoring of immunosuppressive medicine and for predicting infections.
Complete-blood samples have been stimulated with anti-CD3/toll-like-receptor (TLR7/8)-agonist within the presence or absence of medication and IFN-γ secretion was measured by ELISA. Extra stimulation-induced cytokines have been characterised amongst T-, B-, and NK-cells utilizing flow-cytometry.
Cytokine-secretion was dominated by IFN-γ, and primarily noticed in CD4, CD8, and NK-cells. Intra-assay variability was low (CV = 10.4 ± 6.2%), whereas variability over time was excessive, even within the absence of scientific occasions (CV = 65.0 ± 35.7%).
Cyclosporine A, tacrolimus and steroids dose-dependently inhibited IFN-γ secretion, and reactivity was additional decreased when calcineurin inhibitors have been mixed with steroids. Furthermore, IFN-γ ranges considerably differed between controls, dialysis-patients, and transplant-recipients, with lowest IFN-γ ranges early after transplantation (p < 0.001).
Nonetheless, a single take a look at had restricted skill to foretell infectious episodes. In conclusion, the assay could have potential for primary pharmacodynamic characterization of immunosuppressive medicine and their combos, and for assessing lack of international immunocompetence after transplantation, however its utility to information drug-dosing and to foretell infectious on a person foundation is proscribed.
Key phrases: T-cell; immunomonitoring; immunosuppression; an infection; pharmacodynamics; pharmacokinetics; transplantation.
DNMT3A Antibody |
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| 32580-100ul | SAB | 100ul | EUR 302.4 |
Dnmt3a Antibody |
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| 48869-100ul | SAB | 100ul | EUR 399.6 |
Dnmt3a Antibody |
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| 48869-50ul | SAB | 50ul | EUR 286.8 |
DNMT3A Antibody |
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| ABD6795 | Lifescience Market | 100 ug | EUR 525.6 |
DNMT3A Antibody |
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| ABD7226 | Lifescience Market | 100 ug | EUR 525.6 |
DNMT3A Antibody |
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| DF7226 | Affbiotech | 200ul | EUR 420 |
DNMT3A Antibody |
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| DF6795 | Affbiotech | 200ul | EUR 420 |
DNMT3A Antibody |
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| 1-CSB-PA045919 | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:100-1:300 |
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DNMT3A Antibody |
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| 1-CSB-PA094007 | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:100-1:300 |
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DNMT3A Antibody |
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| 1-CSB-PA522891 | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
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DNMT3A Antibody |
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| 1-CSB-PA632606 | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
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DNMT3A Antibody |
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| 1-CSB-PA007083GA01HU | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC |
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DNMT3A Antibody |
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| 1-CSB-PA007083LA01HU | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 |
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Dnmt3a Antibody |
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| F53021-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
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Dnmt3a Antibody |
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| F53021-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
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Dnmt3a Antibody |
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| F40558-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. |
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Dnmt3a Antibody |
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| F40558-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. |
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Dnmt3a Antibody |
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| F40603-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: Dnmt3a is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt] |
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Dnmt3a Antibody |
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| F40603-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: Dnmt3a is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt] |
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Dnmt3a Antibody |
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| F40604-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [Wiki] |
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Dnmt3a Antibody |
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| F40604-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [Wiki] |
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Dnmt3a Antibody |
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| F40605-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: DNA (cytosine-5)-methyltransferase 3A is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called DNA methylation. The enzyme is encoded in humans by the DNMT3A gene. [Wiki] |
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Dnmt3a Antibody |
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| F40605-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: DNA (cytosine-5)-methyltransferase 3A is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called DNA methylation. The enzyme is encoded in humans by the DNMT3A gene. [Wiki] |
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Dnmt3a Antibody |
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| F44361-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. |
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Dnmt3a Antibody |
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| F44361-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
|
Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. |
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Dnmt3a Antibody |
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| F44638-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. |
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Dnmt3a Antibody |
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| F44638-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
|
Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. |
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DNMT3A Antibody, HRP conjugated |
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| 1-CSB-PA007083LB01HU | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
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DNMT3A Antibody, FITC conjugated |
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| 1-CSB-PA007083LC01HU | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
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DNMT3A Antibody, Biotin conjugated |
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| 1-CSB-PA007083LD01HU | Cusabio |
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Description: A polyclonal antibody against DNMT3A. Recognizes DNMT3A from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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Dnmt3a Conjugated Antibody |
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| C48869 | SAB | 100ul | EUR 476.4 |
DNMT3A Conjugated Antibody |
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| C32580 | SAB | 100ul | EUR 476.4 |
DNMT3A polyclonal antibody |
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| 6849-25 | Biovision | each | EUR 444 |
DNMT3A Polyclonal Antibody |
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| A-1003 | EpiGentek |
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DNMT3A Polyclonal Antibody |
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| A52569 | EpiGentek |
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DNA Methyltransferase 3A (DNMT3A) Antibody |
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| 20-abx176189 | Abbexa |
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DNA Methyltransferase 3A (DNMT3A) Antibody |
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| 20-abx172144 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx241133 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx232484-100ug | Abbexa | 100 ug | EUR 577.2 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx232485-100ug | Abbexa | 100 ug | EUR 577.2 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx241502 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx241503 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx214976 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx121083 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx146860-100ug | Abbexa | 100 ug | EUR 526.8 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx146861-100ug | Abbexa | 100 ug | EUR 526.8 |
DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody |
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| abx025680-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody |
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| abx025680-80l | Abbexa | 80 µl | EUR 343.2 |
DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody |
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| abx025681-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody |
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| abx025681-80l | Abbexa | 80 µl | EUR 343.2 |
DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody |
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| abx025682-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody |
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| abx025682-80l | Abbexa | 80 µl | EUR 343.2 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx036882-100ug | Abbexa | 100 ug | EUR 469.2 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx028472-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx028472-80l | Abbexa | 80 µl | EUR 343.2 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx028700-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| abx028700-80l | Abbexa | 80 µl | EUR 343.2 |
DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx125327 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx125773 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx001682 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx002272 | Abbexa |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody |
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| 20-abx004987 | Abbexa |
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DNA (cytosine-5) Methyltransferase3A (DNMT3A) Antibody |
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| 20-abx109726 | Abbexa |
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DNMT3A Polyclonal Antibody, HRP Conjugated |
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| A52570 | EpiGentek |
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DNA Methyltransferase 3 Alpha (DNMT3A) Antibody Pair |
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| abx117617-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
DNMT3A Polyclonal Antibody, FITC Conjugated |
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| A52571 | EpiGentek |
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DNA (cytosine-5)-Methyltransferase 3A (DNMT3A) Antibody |
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| abx224287-100ug | Abbexa | 100 ug | EUR 493.2 |
DNA (cytosine-5)-Methyltransferase 3A (DNMT3A) Antibody |
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| abx025649-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA (cytosine-5)-Methyltransferase 3A (DNMT3A) Antibody |
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| abx025649-80l | Abbexa | 80 µl | EUR 343.2 |
DNMT3A Polyclonal Antibody, Biotin Conjugated |
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| A52572 | EpiGentek |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC941898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF594 conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC941898-500 | Biotium | 500uL | EUR 654 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF594 conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC801898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF680 conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC801898-500 | Biotium | 500uL | EUR 654 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF680 conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC701898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF770 conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC701898-500 | Biotium | 500uL | EUR 654 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF770 conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC881898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF488A conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC881898-500 | Biotium | 500uL | EUR 654 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF488A conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC811898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF680R conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC811898-500 | Biotium | 500uL | EUR 654 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF680R conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC051898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF405M conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC051898-500 | Biotium | 500uL | EUR 654 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF405M conjugate, Concentration: 0.1mg/mL |
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DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2) Antibody |
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| BNC041898-100 | Biotium | 100uL | EUR 279.6 |
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Description: Primary antibody against DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF405S conjugate, Concentration: 0.1mg/mL |
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