Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.

 

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.

Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.

Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.

 

The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.

 

The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.

 

 

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.

To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.

 

Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.

 

Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

LDLRAD3 Antibody
39887-100ul	SAB	100ul	EUR 468

LDLRAD3 Antibody
34765-100ul	SAB	100ul	EUR 302.4

LDLRAD3 Antibody
34765-50ul	SAB	50ul	EUR 224.4

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 418.8

LDLRAD3 Polyclonal Antibody
ABP53840-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Conjugated Antibody
C34765	SAB	100ul	EUR 476.4

LDLRAD3 Polyclonal Antibody
ES4839-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody
ES4839-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 siRNA
20-abx922395	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

LDLRAD3 siRNA
20-abx922396	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

LDLRAD3 cloning plasmid
CSB-CL803154HU-10ug	Cusabio	10ug	EUR 481.2
Description: A cloning plasmid for the LDLRAD3 gene.

LDLRAD3 Blocking Peptide
33R-1897	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224

LDLRAD3 Blocking Peptide
20-abx162318	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

Polyclonal LDLRAD3 antibody - middle region
APR01194G	Leading Biology	0.05mg	EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications:

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 336

Mouse LDLRAD3 shRNA Plasmid
20-abx982528	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human LDLRAD3 shRNA Plasmid
20-abx965371	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human LDLRAD3 ELISA KIT
ELI-39778h	Lifescience Market	96 Tests	EUR 988.8

Mouse Ldlrad3 ELISA KIT
ELI-27814m	Lifescience Market	96 Tests	EUR 1038

LDLRAD3 Recombinant Protein (Human)
RP040687	ABM	100 ug	Ask for price

LDLRAD3 Recombinant Protein (Mouse)
RP147182	ABM	100 ug	Ask for price

anti- Lin28A-specific antibody
FNab04784	FN Test	100µg	EUR 658.5
Description: Antibody raised against Lin28A-specific

anti- Lin28B-specific antibody
FNab04786	FN Test	100µg	EUR 702
Description: Antibody raised against Lin28B-specific

anti- LRP2-Specific antibody
FNab04847	FN Test	100µg	EUR 702
Description: Antibody raised against LRP2-Specific

anti- MAS1L-Specific antibody
FNab05020	FN Test	100µg	EUR 702
Description: Antibody raised against MAS1L-Specific

anti- MCL1L-specific antibody
FNab05054	FN Test	100µg	EUR 606.3
Description: Antibody raised against MCL1L-specific

anti- MDM1-Specific antibody
FNab05076	FN Test	100µg	EUR 658.5
Description: Antibody raised against MDM1-Specific

anti- MEF2C-Specific antibody
FNab05107	FN Test	100µg	EUR 606.3
Description: Antibody raised against MEF2C-Specific

anti- MYH10-Specific antibody
FNab05472	FN Test	100µg	EUR 606.3
Description: Antibody raised against MYH10-Specific

anti- MYH4-Specific antibody
FNab05476	FN Test	100µg	EUR 658.5
Description: Antibody raised against MYH4-Specific

anti- MYH7-specific antibody
FNab05478	FN Test	100µg	EUR 658.5
Description: Antibody raised against MYH7-specific

anti- MYOM1-Specific antibody
FNab05516	FN Test	100µg	EUR 606.3
Description: Antibody raised against MYOM1-Specific

anti- MYPN-Specific antibody
FNab05525	FN Test	100µg	EUR 702
Description: Antibody raised against MYPN-Specific

anti- MYSM1-Specific antibody
FNab05527	FN Test	100µg	EUR 702
Description: Antibody raised against MYSM1-Specific

anti- NARFL-Specific antibody
FNab05553	FN Test	100µg	EUR 658.5
Description: Antibody raised against NARFL-Specific

anti- NEB-Specific antibody
FNab05638	FN Test	100µg	EUR 658.5
Description: Antibody raised against NEB-Specific

anti- Neogenin-Specific antibody
FNab05662	FN Test	100µg	EUR 606.3
Description: Antibody raised against Neogenin-Specific

anti- neurturin-Specific antibody
FNab05683	FN Test	100µg	EUR 702
Description: Antibody raised against neurturin-Specific

anti- NFIX-Specific antibody
FNab05701	FN Test	100µg	EUR 658.5
Description: Antibody raised against NFIX-Specific

anti- NOX3-Specific antibody
FNab05805	FN Test	100µg	EUR 658.5
Description: Antibody raised against NOX3-Specific

anti- OCT2-Specific antibody
FNab05962	FN Test	100µg	EUR 606.3
Description: Antibody raised against OCT2-Specific

anti- Oct6-Specific antibody
FNab05965	FN Test	100µg	EUR 606.3
Description: Antibody raised against Oct6-Specific

anti- ORM2-Specific antibody
FNab06014	FN Test	100µg	EUR 702
Description: Antibody raised against ORM2-Specific

anti- PACS2-Specific antibody
FNab06099	FN Test	100µg	EUR 606.3
Description: Antibody raised against PACS2-Specific

anti- Palladin-Specific antibody
FNab06127	FN Test	100µg	EUR 702
Description: Antibody raised against Palladin-Specific

anti- PAX1-Specific antibody
FNab06167	FN Test	100µg	EUR 658.5
Description: Antibody raised against PAX1-Specific

anti- PAX8-Specific antibody
FNab06177	FN Test	100µg	EUR 702
Description: Antibody raised against PAX8-Specific

anti- persephin-Specific antibody
FNab06323	FN Test	100µg	EUR 702
Description: Antibody raised against persephin-Specific

anti- PFKFB3-Specific antibody
FNab06339	FN Test	100µg	EUR 606.3
Description: Antibody raised against PFKFB3-Specific

anti- PKM1-specific antibody
FNab06494	FN Test	100µg	EUR 658.5
Description: Antibody raised against PKM1-specific

anti- PKM2-specific antibody
FNab06495	FN Test	100µg	EUR 658.5
Description: Antibody raised against PKM2-specific

anti- PKM2-specific antibody
FNab06496	FN Test	100µg	EUR 658.5
Description: Antibody raised against PKM2-specific

anti- PLOD2-Specific antibody
FNab06552	FN Test	100µg	EUR 606.3
Description: Antibody raised against PLOD2-Specific

anti- POLR2B-Specific antibody
FNab06620	FN Test	100µg	EUR 606.3
Description: Antibody raised against POLR2B-Specific

anti- POTEA-Specific antibody
FNab06647	FN Test	100µg	EUR 702
Description: Antibody raised against POTEA-Specific

anti- POTED-Specific antibody
FNab06648	FN Test	100µg	EUR 702
Description: Antibody raised against POTED-Specific

anti- POU3F3-Specific antibody
FNab06651	FN Test	100µg	EUR 606.3
Description: Antibody raised against POU3F3-Specific

anti- PPIF-Specific antibody
FNab06676	FN Test	100µg	EUR 606.3
Description: Antibody raised against PPIF-Specific

anti- PPP1CB-Specific antibody
FNab06695	FN Test	100µg	EUR 606.3
Description: Antibody raised against PPP1CB-Specific

anti- PPP1R11-Specific antibody
FNab06699	FN Test	100µg	EUR 702
Description: Antibody raised against PPP1R11-Specific

anti- PSEN2-Specific antibody
FNab06853	FN Test	100µg	EUR 658.5
Description: Antibody raised against PSEN2-Specific

anti- PTH-Specific antibody
FNab06923	FN Test	100µg	EUR 702
Description: Antibody raised against PTH-Specific

anti- PYGM-Specific antibody
FNab06977	FN Test	100µg	EUR 658.5
Description: Antibody raised against PYGM-Specific

anti- RAB11B-Specific antibody
FNab06989	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB11B-Specific

anti- RAB11-Specific antibody
FNab06994	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB11-Specific

anti- RAB22A-specific antibody
FNab07005	FN Test	100µg	EUR 702
Description: Antibody raised against RAB22A-specific

anti- RAB27A-specific antibody
FNab07011	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB27A-specific

anti- RAB31-specific antibody
FNab07015	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB31-specific

anti- RAB3A-specific antibody
FNab07025	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB3A-specific

anti- RAB3C-specific antibody
FNab07028	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB3C-specific

anti- RAB5A-Specific antibody
FNab07039	FN Test	100µg	EUR 702
Description: Antibody raised against RAB5A-Specific

anti- RAB9A-Specific antibody
FNab07049	FN Test	100µg	EUR 606.3
Description: Antibody raised against RAB9A-Specific

anti- REDD1 specific antibody
FNab07228	FN Test	100µg	EUR 658.5
Description: Antibody raised against REDD1 specific

anti- RIM2-Specific antibody
FNab07301	FN Test	100µg	EUR 658.5
Description: Antibody raised against RIM2-Specific

anti- RIMS4-Specific antibody
FNab07305	FN Test	100µg	EUR 658.5
Description: Antibody raised against RIMS4-Specific

anti- RIPK1-Specific antibody
FNab07313	FN Test	100µg	EUR 658.5
Description: Antibody raised against RIPK1-Specific

anti- ROBO1-Specific antibody
FNab07372	FN Test	100µg	EUR 658.5
Description: Antibody raised against ROBO1-Specific

anti- ROBO3-Specific antibody
FNab07374	FN Test	100µg	EUR 658.5
Description: Antibody raised against ROBO3-Specific

anti- ROBO4-Specific antibody
FNab07375	FN Test	100µg	EUR 658.5
Description: Antibody raised against ROBO4-Specific

anti- ROCK1-Specific antibody
FNab07377	FN Test	100µg	EUR 658.5
Description: Antibody raised against ROCK1-Specific

anti- ROCK2-Specific antibody
FNab07379	FN Test	100µg	EUR 658.5
Description: Antibody raised against ROCK2-Specific

anti- RRM1-Specific antibody
FNab07495	FN Test	100µg	EUR 658.5
Description: Antibody raised against RRM1-Specific

anti- RtcB-Specific antibody
FNab07515	FN Test	100µg	EUR 658.5
Description: Antibody raised against RtcB-Specific

p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).

 

In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.

 

Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice

 

 

anti- STAT3 antibody
FNab08300	FN Test	100µg	EUR 658.5
Description: Antibody raised against STAT3

Anti-STAT3 antibody
PAab08298	Lifescience Market	100 ug	EUR 463.2

Anti-STAT3 antibody
PAab08299	Lifescience Market	100 ug	EUR 463.2

Anti-STAT3 Antibody
PB9511	BosterBio	100ug/vial	EUR 352.8

Anti-STAT3 antibody
STJ113436	St John's Laboratory	50 µl	EUR 344.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ113737	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ27462	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ29841	St John's Laboratory	100 µl	EUR 495.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 Antibody
STJ503137	St John's Laboratory	100 µg	EUR 571.2

Anti-STAT3 antibody
STJ70982	St John's Laboratory	100 µg	EUR 430.8

Anti-STAT3 antibody
STJ118189	St John's Laboratory	100 µl	EUR 332.4

Anti-STAT3 antibody
STJ119281	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Stat3 antibody
STJ95808	St John's Laboratory	200 µl	EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ95808 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Stat3 protein.

Anti-Stat3 antibody
STJ95809	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ95810	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ97467	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ97468	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-STAT3 antibody
STJ97520	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to STAT3 (1E3).

Anti-STAT3 antibody
STJ97525	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to STAT3 (3F4).

Anti-Stat3 antibody
STJ98399	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Stat3.

Anti-Stat3 antibody
STJ98400	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Stat3.

Anti-STAT3 antibody
STJ99212	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to STAT3.

anti-STAT3
YF-PA14814	Abfrontier	50 ug	EUR 435.6
Description: Mouse polyclonal to STAT3

Anti-Phospho-STAT3 Antibody
STJ502696	St John's Laboratory	100 µg	EUR 703.2

Anti-STAT3 Antibody (Biotin)
STJ503138	St John's Laboratory	100 µg	EUR 703.2

Anti-STAT3 Antibody (FITC)
STJ503139	St John's Laboratory	100 µg	EUR 703.2

anti-STAT3 (7G3H4)
LF-MA30243	Abfrontier	100 ul	EUR 583.2
Description: Mouse Monoclonal to STAT3

anti-STAT3 (3B5)
LF-MA30485	Abfrontier	100 ul	EUR 583.2
Description: Mouse Monoclonal to STAT3

Anti-STAT3 (4D6)
YF-MA10886	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to STAT3

Polyclonal Goat Anti-STAT3 Antibody
APG00319G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STAT3 . This antibody is tested and proven to work in the following applications:

Anti-STAT3 Rabbit Monoclonal Antibody
M00007	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody
M00007-1	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody
M00007-2	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IP, IF, WB and tested in Human.

Anti-Phospho-STAT3-(Y705) antibody
STJ27511	St John's Laboratory	100 µl	EUR 471.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Phospho-STAT3 Antibody BIOTIN
STJ502697	St John's Laboratory	100 µg	EUR 774

Anti-Phospho-STAT3 Antibody FITC
STJ502698	St John's Laboratory	100 µg	EUR 774

Anti-Phospho-Stat3 (S727) antibody
STJ90410	St John's Laboratory	200 µl	EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90410 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about S727 when S727 is phosphorylated.

Anti-Phospho-Stat3 (Y705) antibody
STJ90411	St John's Laboratory	200 µl	EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about Y705 when Y705 is phosphorylated.

Anti-Stat3 (Acetyl-Lys49) Antibody
STJ193228	St John's Laboratory	200 µl	EUR 236.4

Anti-Stat3 (Acetyl Lys87) antibody
STJ97699	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3 (Acetyl Lys87).

Anti-Phospho-Stat3 (Y705) antibody
STJ97747	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to Phospho-Stat3 (Y705).

Anti-Phospho-STAT3-(S727) antibody
STJ116371	St John's Laboratory	100 µl	EUR 471.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Hu-48T	DL Develop	48T	EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Hu-96T	DL Develop	96T	EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Mu-48T	DL Develop	48T	EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Mu-96T	DL Develop	96T	EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Ra-48T	DL Develop	48T	EUR 633.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Ra-96T	DL Develop	96T	EUR 828
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Hu-48Tests	Reddot Biotech	48 Tests	EUR 600

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Hu-96Tests	Reddot Biotech	96 Tests	EUR 830.4

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Mu-48Tests	Reddot Biotech	48 Tests	EUR 613.2

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Mu-96Tests	Reddot Biotech	96 Tests	EUR 850.8

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Ra-48Tests	Reddot Biotech	48 Tests	EUR 640.8

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Ra-96Tests	Reddot Biotech	96 Tests	EUR 890.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Hu-48Tests	Reddot Biotech	48 Tests	EUR 626.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Hu-96Tests	Reddot Biotech	96 Tests	EUR 868.8

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Mu-48Tests	Reddot Biotech	48 Tests	EUR 640.8

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Mu-96Tests	Reddot Biotech	96 Tests	EUR 890.4

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Ra-48Tests	Reddot Biotech	48 Tests	EUR 669.6

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Ra-96Tests	Reddot Biotech	96 Tests	EUR 931.2

STAT3 Antibody
1-CSB-PA080245	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

STAT3 Antibody
1-CSB-PA050164	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

STAT3 Antibody
1-CSB-PA004173	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

STAT3 Antibody
1-CSB-PA004174	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

STAT3 Antibody
AF7800	Affbiotech	200ul	EUR 540

STAT3 Antibody
AF5205	Affbiotech	200ul	EUR 420

STAT3 Antibody
AF6293	Affbiotech	200ul	EUR 420

STAT3 Antibody
AF6294	Affbiotech	200ul	EUR 420

STAT3 Antibody
AF6295	Affbiotech	200ul	EUR 420

STAT3 Antibody
1-CSB-PA022812GA01HU	Cusabio	EUR 716.40 EUR 399.60	150ul 50ul
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

STAT3 Antibody
1-CSB-PA022812LA01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000

STAT3 antibody
70R-37485	Fitzgerald	100 ug	EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody
70R-37486	Fitzgerald	100 ug	EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody
70R-50431	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50432	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50433	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-35948	Fitzgerald	100 ug	EUR 418.8
Description: Rabbit polyclonal STAT3 antibody

STAT3 Antibody
7197-002mg	ProSci	0.02 mg	EUR 206.18
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

STAT3 Antibody
7197-01mg	ProSci	0.1 mg	EUR 523.7
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

STAT3 antibody
70R-20573	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-31708	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-32513	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-32515	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-51642	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal STAT3 antibody