Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.

 

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.

Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.

Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.

 

The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.

 

The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.

 

 

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.

To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.

 

Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.

 

Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

LDLRAD3 Antibody
39887-100ul	SAB	100ul	EUR 390

LDLRAD3 antibody
70R-35512	Fitzgerald	100 ug	EUR 327
Description: Purified Rabbit polyclonal LDLRAD3 antibody

LDLRAD3 antibody
70R-9224	Fitzgerald	50 ug	EUR 467
Description: Affinity purified rabbit polyclonal LDLRAD3 antibody

LDLRAD3 antibody
70R-51775	Fitzgerald	100 ul	EUR 244
Description: Purified Polyclonal LDLRAD3 antibody

LDLRAD3 Polyclonal Antibody
ES4839-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody
ES4839-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody
ABP53840-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Conjugated Antibody
C34765	SAB	100ul	EUR 397

LDLRAD3 siRNA
20-abx922395	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

LDLRAD3 siRNA
20-abx922396	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

LDLRAD3 cloning plasmid
CSB-CL803154HU-10ug	Cusabio	10ug	EUR 401
Description: A cloning plasmid for the LDLRAD3 gene.

LDLRAD3 Blocking Peptide
20-abx162318	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

LDLRAD3 Blocking Peptide
33R-1897	Fitzgerald	100 ug	EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224

Polyclonal LDLRAD3 antibody - middle region
APR01194G	Leading Biology	0.05mg	EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications:

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 280

Human LDLRAD3 shRNA Plasmid
20-abx965371	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse LDLRAD3 shRNA Plasmid
20-abx982528	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse Ldlrad3 ELISA KIT
ELI-27814m	Lifescience Market	96 Tests	EUR 865

Human LDLRAD3 ELISA KIT
ELI-39778h	Lifescience Market	96 Tests	EUR 824

LDLRAD3 Recombinant Protein (Human)
RP040687	ABM	100 ug	Ask for price

LDLRAD3 Recombinant Protein (Mouse)
RP147182	ABM	100 ug	Ask for price

anti- BLOC1S1-Specific antibody
FNab00909	FN Test	100µg	EUR 505.25
Description: Antibody raised against BLOC1S1-Specific

anti- BRN2-Specific antibody
FNab00963	FN Test	100µg	EUR 505.25
Description: Antibody raised against BRN2-Specific

anti- CAPG-Specific antibody
FNab01249	FN Test	100µg	EUR 505.25
Description: Antibody raised against CAPG-Specific

anti- Catalase-Specific antibody
FNab01302	FN Test	100µg	EUR 505.25
Description: Antibody raised against Catalase-Specific

anti- CCKAR-specific antibody
FNab01377	FN Test	100µg	EUR 505.25
Description: Antibody raised against CCKAR-specific

anti- CCKBR-specific antibody
FNab01378	FN Test	100µg	EUR 505.25
Description: Antibody raised against CCKBR-specific

anti- CCR2-specific antibody
FNab01390	FN Test	100µg	EUR 505.25
Description: Antibody raised against CCR2-specific

anti- CCT6A-Specific antibody
FNab01401	FN Test	100µg	EUR 505.25
Description: Antibody raised against CCT6A-Specific

anti- CDH10-specific antibody
FNab01546	FN Test	100µg	EUR 505.25
Description: Antibody raised against CDH10-specific

anti- CDK1-Specific antibody
FNab01552	FN Test	100µg	EUR 505.25
Description: Antibody raised against CDK1-Specific

anti- CEACAM3-Specific antibody
FNab01578	FN Test	100µg	EUR 505.25
Description: Antibody raised against CEACAM3-Specific

anti- CEP350-Specific antibody
FNab01603	FN Test	100µg	EUR 505.25
Description: Antibody raised against CEP350-Specific

anti- CES7-Specific antibody
FNab01618	FN Test	100µg	EUR 505.25
Description: Antibody raised against CES7-Specific

anti- CHST13-Specific antibody
FNab01693	FN Test	100µg	EUR 548.75
Description: Antibody raised against CHST13-Specific

anti- CISD2-Specific antibody
FNab01719	FN Test	100µg	EUR 505.25
Description: Antibody raised against CISD2-Specific

anti- CPNE9-Specific antibody
FNab01932	FN Test	100µg	EUR 505.25
Description: Antibody raised against CPNE9-Specific

anti- CPT1B-specific antibody
FNab01944	FN Test	100µg	EUR 548.75
Description: Antibody raised against CPT1B-specific

anti- CPT1C-specific antibody
FNab01946	FN Test	100µg	EUR 505.25
Description: Antibody raised against CPT1C-specific

anti- CRLS1-Specific antibody
FNab01983	FN Test	100µg	EUR 548.75
Description: Antibody raised against CRLS1-Specific

anti- CST2-Specific antibody
FNab02033	FN Test	100µg	EUR 505.25
Description: Antibody raised against CST2-Specific

anti- CSTL1-Specific antibody
FNab02041	FN Test	100µg	EUR 505.25
Description: Antibody raised against CSTL1-Specific

anti- CUL4A-Specific antibody
FNab02078	FN Test	100µg	EUR 505.25
Description: Antibody raised against CUL4A-Specific

anti- CXCR3B-specific antibody
FNab02101	FN Test	100µg	EUR 505.25
Description: Antibody raised against CXCR3B-specific

anti- CXCR7-Specific antibody
FNab02107	FN Test	100µg	EUR 548.75
Description: Antibody raised against CXCR7-Specific

anti- CYP1A2-Specific antibody
FNab02148	FN Test	100µg	EUR 505.25
Description: Antibody raised against CYP1A2-Specific

anti- CYP2E1-Specific antibody
FNab02159	FN Test	100µg	EUR 505.25
Description: Antibody raised against CYP2E1-Specific

anti- CYP4F11-Specific antibody
FNab02171	FN Test	100µg	EUR 505.25
Description: Antibody raised against CYP4F11-Specific

anti- CYP4Z1-Specific antibody
FNab02175	FN Test	100µg	EUR 505.25
Description: Antibody raised against CYP4Z1-Specific

anti- DAPK2-Specific antibody
FNab02241	FN Test	100µg	EUR 548.75
Description: Antibody raised against DAPK2-Specific

anti- DCC-Specific antibody
FNab02262	FN Test	100µg	EUR 505.25
Description: Antibody raised against DCC-Specific

anti- DGKK-Specific antibody
FNab02360	FN Test	100µg	EUR 585
Description: Antibody raised against DGKK-Specific

anti- DLL1-Specific antibody
FNab02415	FN Test	100µg	EUR 585
Description: Antibody raised against DLL1-Specific

anti- DOCK180-Specific antibody
FNab02493	FN Test	100µg	EUR 505.25
Description: Antibody raised against DOCK180-Specific

anti- DR5-Specific antibody
FNab02530	FN Test	100µg	EUR 585
Description: Antibody raised against DR5-Specific

anti- EDG7-Specific antibody
FNab02635	FN Test	100µg	EUR 505.25
Description: Antibody raised against EDG7-Specific

anti- EGFR-Specific antibody
FNab02669	FN Test	100µg	EUR 505.25
Description: Antibody raised against EGFR-Specific

anti- EIF2C1-Specific antibody
FNab02697	FN Test	100µg	EUR 505.25
Description: Antibody raised against EIF2C1-Specific

anti- EIF2C3-Specific antibody
FNab02698	FN Test	100µg	EUR 505.25
Description: Antibody raised against EIF2C3-Specific

anti- EPHA1-specific antibody
FNab02801	FN Test	100µg	EUR 548.75
Description: Antibody raised against EPHA1-specific

anti- EPHA6-Specific antibody
FNab02804	FN Test	100µg	EUR 505.25
Description: Antibody raised against EPHA6-Specific

anti- FABP7-Specific antibody
FNab02937	FN Test	100µg	EUR 585
Description: Antibody raised against FABP7-Specific

anti- FANCA-Specific antibody
FNab03004	FN Test	100µg	EUR 585
Description: Antibody raised against FANCA-Specific

anti- FcRn-Specific antibody
FNab03063	FN Test	100µg	EUR 585
Description: Antibody raised against FcRn-Specific

anti- FGF16-Specific antibody
FNab03091	FN Test	100µg	EUR 505.25
Description: Antibody raised against FGF16-Specific

anti- FMO2-specific antibody
FNab03169	FN Test	100µg	EUR 548.75
Description: Antibody raised against FMO2-specific

anti- FMO5-specific antibody
FNab03171	FN Test	100µg	EUR 548.75
Description: Antibody raised against FMO5-specific

anti- FOXH1-Specific antibody
FNab03196	FN Test	100µg	EUR 548.75
Description: Antibody raised against FOXH1-Specific

anti- FOXL2-Specific antibody
FNab03199	FN Test	100µg	EUR 505.25
Description: Antibody raised against FOXL2-Specific

anti- GAB3-Specific antibody
FNab03273	FN Test	100µg	EUR 505.25
Description: Antibody raised against GAB3-Specific

anti- GABARAPL1-Specific antibody
FNab03276	FN Test	100µg	EUR 505.25
Description: Antibody raised against GABARAPL1-Specific

anti- GABARAPL2-Specific antibody
FNab03278	FN Test	100µg	EUR 505.25
Description: Antibody raised against GABARAPL2-Specific

anti- GAC-specific antibody
FNab03290	FN Test	100µg	EUR 505.25
Description: Antibody raised against GAC-specific

anti- GATA4-Specific antibody
FNab03363	FN Test	100µg	EUR 505.25
Description: Antibody raised against GATA4-Specific

anti- GEFT-Specific antibody
FNab03416	FN Test	100µg	EUR 548.75
Description: Antibody raised against GEFT-Specific

anti- GLI2-Specific antibody
FNab03477	FN Test	100µg	EUR 505.25
Description: Antibody raised against GLI2-Specific

anti- GLI3-Specific antibody
FNab03478	FN Test	100µg	EUR 505.25
Description: Antibody raised against GLI3-Specific

anti- GPR101-Specific antibody
FNab03587	FN Test	100µg	EUR 585
Description: Antibody raised against GPR101-Specific

anti- GPR123-Specific antibody
FNab03592	FN Test	100µg	EUR 585
Description: Antibody raised against GPR123-Specific

anti- GPR139-Specific antibody
FNab03596	FN Test	100µg	EUR 505.25
Description: Antibody raised against GPR139-Specific

anti- GPRASP1-Specific antibody
FNab03612	FN Test	100µg	EUR 585
Description: Antibody raised against GPRASP1-Specific

anti- GPRIN3-Specific antibody
FNab03616	FN Test	100µg	EUR 548.75
Description: Antibody raised against GPRIN3-Specific

anti- HBA1-Specific antibody
FNab03767	FN Test	100µg	EUR 585
Description: Antibody raised against HBA1-Specific

p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).

 

In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.

 

Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice

 

 

Anti-Stat3 antibody
STJ95808	St John's Laboratory	200 µl	EUR 197
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ95808 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Stat3 protein.

Anti-Stat3 antibody
STJ95809	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ95810	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ98399	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Stat3.

Anti-Stat3 antibody
STJ98400	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Stat3.

Anti-STAT3 antibody
STJ99212	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to STAT3.

Anti-Stat3 antibody
STJ97467	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ97468	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Stat3.

Anti-STAT3 antibody
STJ97520	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to STAT3 (1E3).

Anti-STAT3 antibody
STJ97525	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to STAT3 (3F4).

Anti-STAT3 antibody
STJ29841	St John's Laboratory	100 µl	EUR 413
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 Antibody
STJ503137	St John's Laboratory	100 µg	EUR 476

Anti-STAT3 antibody
STJ70982	St John's Laboratory	100 µg	EUR 359

Anti-STAT3 antibody
STJ118189	St John's Laboratory	100 µl	EUR 277

Anti-STAT3 antibody
STJ119281	St John's Laboratory	100 µl	EUR 277
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ113436	St John's Laboratory	50 µl	EUR 287
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ113737	St John's Laboratory	100 µl	EUR 277
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

anti- STAT3 antibody
FNab08298	FN Test	100µg	EUR 548.75
Description: Antibody raised against STAT3

anti- STAT3 antibody
FNab08299	FN Test	100µg	EUR 548.75
Description: Antibody raised against STAT3

anti- STAT3 antibody
FNab08300	FN Test	100µg	EUR 548.75
Description: Antibody raised against STAT3

Anti-STAT3 Antibody
A1670-100	Biovision		EUR 479

Anti-STAT3 antibody
PAab08298	Lifescience Market	100 ug	EUR 386

Anti-STAT3 antibody
PAab08299	Lifescience Market	100 ug	EUR 386

anti-STAT3
YF-PA14814	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to STAT3

Anti-Phospho-STAT3 Antibody
STJ502696	St John's Laboratory	100 µg	EUR 586

Anti-STAT3 Antibody (Biotin)
STJ503138	St John's Laboratory	100 µg	EUR 586

Anti-STAT3 Antibody (FITC)
STJ503139	St John's Laboratory	100 µg	EUR 586

anti-STAT3 (7G3H4)
LF-MA30243	Abfrontier	100 ul	EUR 486
Description: Mouse Monoclonal to STAT3

anti-STAT3 (3B5)
LF-MA30485	Abfrontier	100 ul	EUR 486
Description: Mouse Monoclonal to STAT3

Anti-STAT3 (4D6)
YF-MA10886	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to STAT3

Anti-STAT3 Rabbit Monoclonal Antibody
M00007	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody
M00007-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody
M00007-2	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IP, IF, WB and tested in Human.

Anti-Phospho-STAT3-(Y705) antibody
STJ27511	St John's Laboratory	100 µl	EUR 393
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Phospho-Stat3 (S727) antibody
STJ90410	St John's Laboratory	200 µl	EUR 197
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90410 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about S727 when S727 is phosphorylated.

Anti-Phospho-Stat3 (Y705) antibody
STJ90411	St John's Laboratory	200 µl	EUR 197
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about Y705 when Y705 is phosphorylated.

Anti-Stat3 (Acetyl Lys87) antibody
STJ97699	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Stat3 (Acetyl Lys87).

Anti-Phospho-Stat3 (Y705) antibody
STJ97747	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Phospho-Stat3 (Y705).

Anti-Stat3 (Acetyl-Lys49) Antibody
STJ193228	St John's Laboratory	200 µl	EUR 197

Anti-Phospho-STAT3 Antibody BIOTIN
STJ502697	St John's Laboratory	100 µg	EUR 645

Anti-Phospho-STAT3 Antibody FITC
STJ502698	St John's Laboratory	100 µg	EUR 645

Polyclonal Goat Anti-STAT3 Antibody
APG00319G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STAT3 . This antibody is tested and proven to work in the following applications:

Anti-Phospho-STAT3-(S727) antibody
STJ116371	St John's Laboratory	100 µl	EUR 393
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Hu-48T	DL Develop	48T	EUR 498
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Hu-96T	DL Develop	96T	EUR 647
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Mu-48T	DL Develop	48T	EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Mu-96T	DL Develop	96T	EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Ra-48T	DL Develop	48T	EUR 528
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Ra-96T	DL Develop	96T	EUR 690
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Hu-48Tests	Reddot Biotech	48 Tests	EUR 522

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Hu-96Tests	Reddot Biotech	96 Tests	EUR 724

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Mu-48Tests	Reddot Biotech	48 Tests	EUR 534

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Mu-96Tests	Reddot Biotech	96 Tests	EUR 742

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Ra-48Tests	Reddot Biotech	48 Tests	EUR 558

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Ra-96Tests	Reddot Biotech	96 Tests	EUR 776

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Hu-48Tests	Reddot Biotech	48 Tests	EUR 500

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Hu-96Tests	Reddot Biotech	96 Tests	EUR 692

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Ra-48Tests	Reddot Biotech	48 Tests	EUR 534

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Ra-96Tests	Reddot Biotech	96 Tests	EUR 742

STAT3 Antibody
1-CSB-PA050164	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

STAT3 Antibody
1-CSB-PA080245	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

STAT3 Antibody
1-CSB-PA022812GA01HU	Cusabio	EUR 597.00 EUR 333.00	150ul 50ul
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

STAT3 Antibody
1-CSB-PA022812LA01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000

STAT3 Antibody
1-CSB-PA004173	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

STAT3 Antibody
1-CSB-PA004174	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

STAT3 Antibody
43315-100ul	SAB	100ul	EUR 252

STAT3 Antibody
48732-100ul	SAB	100ul	EUR 333

STAT3 Antibody
48732-50ul	SAB	50ul	EUR 239

Stat3 Antibody
48780-100ul	SAB	100ul	EUR 333

Stat3 Antibody
48780-50ul	SAB	50ul	EUR 239

STAT3 Antibody
AF6293	Affbiotech	200ul	EUR 304
Description: STAT3 Antibody detects endogenous levels of total STAT3.

STAT3 Antibody
AF6294	Affbiotech	200ul	EUR 304
Description: STAT3 Antibody detects endogenous levels of total STAT3.

STAT3 Antibody
AF6295	Affbiotech	200ul	EUR 304
Description: STAT3 Antibody detects endogenous levels of total STAT3.

STAT3 Antibody
AF7800	Affbiotech	200ul	EUR 376
Description: STAT3 Antibody detects endogenous levels of STAT3.

STAT3 Antibody
BF0354	Affbiotech	200ul	EUR 376
Description: STAT3 antibody detects endogenous levels of total STAT3.

STAT3 Antibody
AF5205	Affbiotech	200ul	EUR 304
Description: STAT3 Antibody detects endogenous levels of total STAT3.

STAT3 Antibody
ABF5205	Lifescience Market	100 ug	EUR 438

STAT3 Antibody
ABF6293	Lifescience Market	100 ug	EUR 438

STAT3 Antibody
ABF6294	Lifescience Market	100 ug	EUR 438

STAT3 Antibody
ABF6295	Lifescience Market	100 ug	EUR 438

Stat3 Antibody
3470R-100	Biovision		EUR 316

Stat3 Antibody
3470R-30T	Biovision		EUR 146