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Posted inAntibodies Assay Kits Biology Cells cDNA Clia Kits Culture Cells Devices DNA DNA Templates Elisa Kits Enzymes Equipments Exosomes Gels Isotypes Medium & Serums NATtrol Panel Particles PCR Pcr Kits Peptides Reagents Recombinant Proteins Ria Kits RNA Test Kits Vector & Virus Western Blot

Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

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Posted By Martin Posted on August 22, 2020
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Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.

 

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.

Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.

Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.

 

The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.

 

The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.

 

 

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.

To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.

 

Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.

 

Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

chipgrade
chipgrade

LDLRAD3 Antibody

CSB-PA786511- Cusabio
EUR 402
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

LDLRAD3 Antibody

CSB-PA786511-100ul Cusabio 100ul
EUR 379.2
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

LDLRAD3 Antibody

1-CSB-PA007326 Cusabio
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN ImmunoStep 50 µg
EUR 418.8

LDLRAD3 Polyclonal Antibody

ABP53840-003ml Abbkine 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody

ABP53840-01ml Abbkine 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody

ABP53840-02ml Abbkine 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Conjugated Antibody

C34765 SAB 100ul
EUR 476.4

LDLRAD3 Polyclonal Antibody

ES4839-100ul ELK Biotech 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody

ES4839-50ul ELK Biotech 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 siRNA

20-abx922395 Abbexa
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

LDLRAD3 siRNA

20-abx922396 Abbexa
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

LDLRAD3 Blocking Peptide

33R-1897 Fitzgerald 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224

LDLRAD3 Blocking Peptide

20-abx162318 Abbexa
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

LDLRAD3 cloning plasmid

CSB-CL803154HU-10ug Cusabio 10ug
EUR 481.2
Description: A cloning plasmid for the LDLRAD3 gene.

Polyclonal LDLRAD3 antibody - middle region

APR01194G Leading Biology 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications:

Human LDLRAD3 shRNA Plasmid

20-abx965371 Abbexa
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse LDLRAD3 shRNA Plasmid

20-abx982528 Abbexa
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human LDLRAD3 ELISA KIT

ELI-39778h Lifescience Market 96 Tests
EUR 988.8

Mouse Ldlrad3 ELISA KIT

ELI-27814m Lifescience Market 96 Tests
EUR 1038

LDLRAD3 Recombinant Protein (Human)

RP040687 ABM 100 ug Ask for price

LDLRAD3 Recombinant Protein (Mouse)

RP147182 ABM 100 ug Ask for price

Polyclonal Goat anti-GST α-form

GST-ANTI-1 Detroit R&D 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 Detroit R&D 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 Detroit R&D 50 uL
EUR 336

Anti-ACADL-Specific antibody

PAab00064 Lifescience Market 100 ug
EUR 426

Anti-ACTA1-Specific antibody

PAab00115 Lifescience Market 100 ug
EUR 426

Anti-ADAM17-Specific antibody

PAab00139 Lifescience Market 100 ug
EUR 426

Anti-ADRA1A-Specific antibody

PAab00177 Lifescience Market 100 ug
EUR 426

Anti-ADRA2B-Specific antibody

PAab00179 Lifescience Market 100 ug
EUR 463.2

Anti-AFF1-Specific antibody

PAab00195 Lifescience Market 100 ug
EUR 426

Anti-AKAP11-Specific antibody

PAab00251 Lifescience Market 100 ug
EUR 426

Anti-AMPD1-Specific antibody

PAab00370 Lifescience Market 100 ug
EUR 463.2

Anti-ARF5-Specific antibody

PAab00534 Lifescience Market 100 ug
EUR 426

Anti-ARF6-Specific antibody

PAab00535 Lifescience Market 100 ug
EUR 426

Anti-ARHGEF9-Specific antibody

PAab00565 Lifescience Market 100 ug
EUR 426

Anti-ARSK-Specific antibody

PAab00613 Lifescience Market 100 ug
EUR 426

Anti-ATF2-Specific antibody

PAab00661 Lifescience Market 100 ug
EUR 426

Anti-ATP1A1-Specific antibody

PAab00692 Lifescience Market 100 ug
EUR 463.2

Anti-ATP1A2-Specific antibody

PAab00694 Lifescience Market 100 ug
EUR 463.2

Anti-ATP5G2-Specific antibody

PAab00708 Lifescience Market 100 ug
EUR 426

Anti-BAG1S-specific antibody

PAab00788 Lifescience Market 100 ug
EUR 463.2

Anti-BAI2-Specific antibody

PAab00791 Lifescience Market 100 ug
EUR 426

Anti-BAI3-Specific antibody

PAab00792 Lifescience Market 100 ug
EUR 426

Anti-Barkor-Specific antibody

PAab00806 Lifescience Market 100 ug
EUR 426

Anti-BLOC1S1-Specific antibody

PAab00909 Lifescience Market 100 ug
EUR 426

Anti-BRN2-Specific antibody

PAab00963 Lifescience Market 100 ug
EUR 426

Anti-BTF3L3-Specific antibody

PAab00976 Lifescience Market 100 ug
EUR 426

Anti-SLC12A5-Specific antibody

PAab07908 Lifescience Market 100 ug
EUR 463.2

Anti-SLC25A6-Specific antibody

PAab07947 Lifescience Market 100 ug
EUR 463.2

Anti-SLIT2-Specific antibody

PAab07981 Lifescience Market 100 ug
EUR 463.2

Anti-SMYD1-Specific antibody

PAab08047 Lifescience Market 100 ug
EUR 463.2

Anti-Somatostatin-Specific antibody

PAab08109 Lifescience Market 100 ug
EUR 463.2

Anti-SPAG4-Specific antibody

PAab08142 Lifescience Market 100 ug
EUR 463.2

Anti-SPIN1-Specific antibody

PAab08178 Lifescience Market 100 ug
EUR 494.4

Anti-SPTBN1-Specific antibody

PAab08204 Lifescience Market 100 ug
EUR 463.2

Anti-SRGAP3-Specific antibody

PAab08227 Lifescience Market 100 ug
EUR 463.2

Anti-ST8SIA2-Specific antibody

PAab08276 Lifescience Market 100 ug
EUR 463.2

Anti-STEAP2-Specific antibody

PAab08317 Lifescience Market 100 ug
EUR 463.2

Anti-SURVIVIN-Specific antibody

PAab08403 Lifescience Market 100 ug
EUR 426

Anti-SYN1-Specific antibody

PAab08416 Lifescience Market 100 ug
EUR 463.2

Anti-TAF1-Specific antibody

PAab08484 Lifescience Market 100 ug
EUR 494.4

Anti-TDRKH specific antibody

PAab08580 Lifescience Market 100 ug
EUR 463.2

Anti-TGFBR3-Specific antibody

PAab08645 Lifescience Market 100 ug
EUR 494.4

Anti-TINAG-Specific antibody

PAab08712 Lifescience Market 100 ug
EUR 494.4

Anti-TMF1-Specific antibody

PAab08796 Lifescience Market 100 ug
EUR 494.4

Anti-TOP2A-Specific antibody

PAab08868 Lifescience Market 100 ug
EUR 494.4

Anti-Tuberin-Specific antibody

PAab09101 Lifescience Market 100 ug
EUR 463.2

Anti-TWIST1-specific antibody

PAab09118 Lifescience Market 100 ug
EUR 494.4

Anti-UBASH3A-Specific antibody

PAab09150 Lifescience Market 100 ug
EUR 463.2

Anti-UBC9-Specific antibody

PAab09159 Lifescience Market 100 ug
EUR 463.2

Anti-UBE2D1-Specific antibody

PAab09167 Lifescience Market 100 ug
EUR 463.2

Anti-UBN1-Specific antibody

PAab09202 Lifescience Market 100 ug
EUR 463.2

Anti-UNC5C-Specific antibody

PAab09263 Lifescience Market 100 ug
EUR 463.2

Anti-UNC5D-Specific antibody

PAab09264 Lifescience Market 100 ug
EUR 494.4

Anti-URB1-Specific antibody

PAab09286 Lifescience Market 100 ug
EUR 494.4

Anti-WASF4-Specific antibody

PAab09469 Lifescience Market 100 ug
EUR 494.4

Anti-YES1-Specific antibody

PAab09563 Lifescience Market 100 ug
EUR 463.2

Anti-ZIC4-Specific antibody

PAab09637 Lifescience Market 100 ug
EUR 494.4

Anti-ZNF600-Specific antibody

PAab09718 Lifescience Market 100 ug
EUR 494.4

Anti-ZNRF2-Specific antibody

PAab09746 Lifescience Market 100 ug
EUR 463.2

Anti-CAPG-Specific antibody

PAab01249 Lifescience Market 100 ug
EUR 426

Anti-Catalase-Specific antibody

PAab01302 Lifescience Market 100 ug
EUR 426

Anti-CCKAR-specific antibody

PAab01377 Lifescience Market 100 ug
EUR 426

Anti-CCKBR-specific antibody

PAab01378 Lifescience Market 100 ug
EUR 426

Anti-CCR2-specific antibody

PAab01390 Lifescience Market 100 ug
EUR 426

Anti-CCT6A-Specific antibody

PAab01401 Lifescience Market 100 ug
EUR 426
×

p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).

 

In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.

 

Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice

 

 

anti- STAT3 antibody

FNab08300 FN Test 100µg
EUR 658.5
Description: Antibody raised against STAT3

Anti-STAT3 Antibody

PA1108 BosterBio 100ug/vial
EUR 400.8

Anti-STAT3 Antibody

PA1778 BosterBio 100ug/vial
EUR 400.8

Anti-STAT3 Antibody

PB9511 BosterBio 100ug/vial
EUR 352.8

Anti-STAT3 antibody

STJ113436 St John's Laboratory 50 µl
EUR 344.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody

STJ113737 St John's Laboratory 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody

STJ118189 St John's Laboratory 100 µl
EUR 332.4

Anti-STAT3 antibody

STJ119281 St John's Laboratory 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Stat3 antibody

STJ98399 St John's Laboratory 100 µl
EUR 280.8
Description: Mouse monoclonal to Stat3.

Anti-Stat3 antibody

STJ98400 St John's Laboratory 100 µl
EUR 280.8
Description: Mouse monoclonal to Stat3.

Anti-STAT3 antibody

STJ99212 St John's Laboratory 200 µl
EUR 236.4
Description: Mouse monoclonal to STAT3.

Anti-Stat3 antibody

STJ95808 St John's Laboratory 200 µl
EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ95808 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Stat3 protein.

Anti-Stat3 antibody

STJ95809 St John's Laboratory 200 µl
EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody

STJ95810 St John's Laboratory 200 µl
EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody

STJ97467 St John's Laboratory 200 µl
EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody

STJ97468 St John's Laboratory 200 µl
EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-STAT3 antibody

STJ97520 St John's Laboratory 200 µl
EUR 236.4
Description: Mouse monoclonal to STAT3 (1E3).

Anti-STAT3 antibody

STJ97525 St John's Laboratory 200 µl
EUR 236.4
Description: Mouse monoclonal to STAT3 (3F4).

Anti-STAT3 antibody

STJ29841 St John's Laboratory 100 µl
EUR 495.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody

STJ27462 St John's Laboratory 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 Antibody

STJ503137 St John's Laboratory 100 µg
EUR 571.2

Anti-STAT3 antibody

STJ70982 St John's Laboratory 100 µg
EUR 430.8

anti-STAT3

YF-PA14814 Abfrontier 50 ug
EUR 435.6
Description: Mouse polyclonal to STAT3

Anti-Phospho-STAT3 Antibody

STJ502696 St John's Laboratory 100 µg
EUR 703.2

Anti-STAT3 Antibody (Biotin)

STJ503138 St John's Laboratory 100 µg
EUR 703.2

Anti-STAT3 Antibody (FITC)

STJ503139 St John's Laboratory 100 µg
EUR 703.2

anti-STAT3 (3B5)

LF-MA30485 Abfrontier 100 ul
EUR 583.2
Description: Mouse Monoclonal to STAT3

anti-STAT3 (7G3H4)

LF-MA30243 Abfrontier 100 ul
EUR 583.2
Description: Mouse Monoclonal to STAT3

Anti-STAT3 (4D6)

YF-MA10886 Abfrontier 100 ug
EUR 435.6
Description: Mouse monoclonal to STAT3

Polyclonal Goat Anti-STAT3 Antibody

APG00319G Leading Biology 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STAT3 . This antibody is tested and proven to work in the following applications:

Anti-STAT3 Rabbit Monoclonal Antibody

M00007 BosterBio 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody

M00007-1 BosterBio 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody

M00007-2 BosterBio 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IP, IF, WB and tested in Human.

Anti-Phospho-STAT3-(S727) antibody

STJ116371 St John's Laboratory 100 µl
EUR 471.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Stat3 (Acetyl Lys87) antibody

STJ97699 St John's Laboratory 200 µl
EUR 236.4
Description: Rabbit polyclonal to Stat3 (Acetyl Lys87).

Anti-Phospho-Stat3 (Y705) antibody

STJ97747 St John's Laboratory 200 µl
EUR 236.4
Description: Mouse monoclonal to Phospho-Stat3 (Y705).

Anti-Phospho-STAT3-(Y705) antibody

STJ27511 St John's Laboratory 100 µl
EUR 471.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Phospho-Stat3 (S727) antibody

STJ90410 St John's Laboratory 200 µl
EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90410 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about S727 when S727 is phosphorylated.

Anti-Phospho-Stat3 (Y705) antibody

STJ90411 St John's Laboratory 200 µl
EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about Y705 when Y705 is phosphorylated.

Anti-Phospho-STAT3 Antibody BIOTIN

STJ502697 St John's Laboratory 100 µg
EUR 774

Anti-Phospho-STAT3 Antibody FITC

STJ502698 St John's Laboratory 100 µg
EUR 774

Anti-Stat3 (Acetyl-Lys49) Antibody

STJ193228 St John's Laboratory 200 µl
EUR 236.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

DLR-STAT3-Hu-48T DL Develop 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

DLR-STAT3-Hu-96T DL Develop 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

DLR-STAT3-Mu-48T DL Develop 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

DLR-STAT3-Mu-96T DL Develop 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

DLR-STAT3-Ra-48T DL Develop 48T
EUR 633.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

DLR-STAT3-Ra-96T DL Develop 96T
EUR 828
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RD-STAT3-Hu-48Tests Reddot Biotech 48 Tests
EUR 600

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RD-STAT3-Hu-96Tests Reddot Biotech 96 Tests
EUR 830.4

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RD-STAT3-Mu-48Tests Reddot Biotech 48 Tests
EUR 613.2

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RD-STAT3-Mu-96Tests Reddot Biotech 96 Tests
EUR 850.8

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RD-STAT3-Ra-48Tests Reddot Biotech 48 Tests
EUR 640.8

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RD-STAT3-Ra-96Tests Reddot Biotech 96 Tests
EUR 890.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RDR-STAT3-Hu-48Tests Reddot Biotech 48 Tests
EUR 626.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RDR-STAT3-Hu-96Tests Reddot Biotech 96 Tests
EUR 868.8

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RDR-STAT3-Mu-48Tests Reddot Biotech 48 Tests
EUR 640.8

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RDR-STAT3-Mu-96Tests Reddot Biotech 96 Tests
EUR 890.4

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RDR-STAT3-Ra-48Tests Reddot Biotech 48 Tests
EUR 669.6

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit

RDR-STAT3-Ra-96Tests Reddot Biotech 96 Tests
EUR 931.2

STAT3 antibody

70R-11848 Fitzgerald 100 ug
EUR 483.6
Description: Rabbit polyclonal STAT3 antibody

STAT3 Antibody

43315-100ul SAB 100ul
EUR 302.4

STAT3 antibody

70R-37485 Fitzgerald 100 ug
EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody

70R-37486 Fitzgerald 100 ug
EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody

70R-50431 Fitzgerald 100 ul
EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-50432 Fitzgerald 100 ul
EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-50433 Fitzgerald 100 ul
EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-20573 Fitzgerald 50 ul
EUR 522
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-35948 Fitzgerald 100 ug
EUR 418.8
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-31708 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-32513 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-32515 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-14315 Fitzgerald 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-51642 Fitzgerald 100 ul
EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-13773 Fitzgerald 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 Antibody

48732-100ul SAB 100ul
EUR 399.6

STAT3 Antibody

48732-50ul SAB 50ul
EUR 286.8

Stat3 Antibody

48780-100ul SAB 100ul
EUR 399.6

Stat3 Antibody

48780-50ul SAB 50ul
EUR 286.8

Stat3 Antibody

3470R-100 Biovision
EUR 379.2

Stat3 Antibody

3470R-30T Biovision
EUR 175.2

STAT3 antibody

10R-5956 Fitzgerald 100 ul
EUR 871.2
Description: Mouse monoclonal STAT3 antibody

STAT3 antibody

10R-1224 Fitzgerald 100 ug
EUR 614.4
Description: Mouse monoclonal STAT3 antibody

Stat3 antibody

20R-1593 Fitzgerald 100 ug
EUR 807.6
Description: Rabbit polyclonal Stat3 antibody
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