Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.

 

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.

Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.

Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.

 

The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.

 

The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.

 

 

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.

To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.

 

Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.

 

Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

LDLRAD3 Antibody
1-CSB-PA007326	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000

LDLRAD3 Conjugated Antibody
C34765	SAB	100ul	EUR 476.4

LDLRAD3 Polyclonal Antibody
ABP53840-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ES4839-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody
ES4839-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

Polyclonal LDLRAD3 antibody - middle region
APR01194G	Leading Biology	0.05mg	EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications:

LDLRAD3 siRNA
20-abx922395	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

LDLRAD3 siRNA
20-abx922396	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

LDLRAD3 cloning plasmid
CSB-CL803154HU-10ug	Cusabio	10ug	EUR 481.2
Description: A cloning plasmid for the LDLRAD3 gene.

LDLRAD3 Blocking Peptide
33R-1897	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224

LDLRAD3 Blocking Peptide
20-abx162318	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

anti- Kv1.4-Specific antibody
FNab04664	FN Test	100µg	EUR 606.3
Description: Antibody raised against Kv1.4-Specific

anti- TDRKH specific antibody
FNab08580	FN Test	100µg	EUR 658.5
Description: Antibody raised against TDRKH specific

anti- TUBB3 specific antibody
FNab09890	FN Test	100µg	EUR 658.5
Description: Antibody raised against TUBB3 specific

anti- REDD1 specific antibody
FNab07228	FN Test	100µg	EUR 658.5
Description: Antibody raised against REDD1 specific

Mouse Ldlrad3 ELISA KIT
ELI-27814m	Lifescience Market	96 Tests	EUR 1038

Human LDLRAD3 ELISA KIT
ELI-39778h	Lifescience Market	96 Tests	EUR 988.8

Anti-Kv1.4-Specific antibody
PAab04664	Lifescience Market	100 ug	EUR 426

Anti-REDD1 specific antibody
PAab07228	Lifescience Market	100 ug	EUR 463.2

Anti-TDRKH specific antibody
PAab08580	Lifescience Market	100 ug	EUR 463.2

Human LDLRAD3 shRNA Plasmid
20-abx965371	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Mouse LDLRAD3 shRNA Plasmid
20-abx982528	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

anti- LDLRAD1 antibody
FNab04743	FN Test	100µg	EUR 658.5
Description: Antibody raised against LDLRAD1

TDRKH Specific (TDRKH specific) Antibody
abx238580-100ug	Abbexa	100 ug	EUR 610.8

REDD1 Specific (REDD1 specific) Antibody
abx237228-100ug	Abbexa	100 ug	EUR 610.8

LDLRAD3 Recombinant Protein (Mouse)
RP147182	ABM	100 ug	Ask for price

LDLRAD3 Recombinant Protein (Human)
RP040687	ABM	100 ug	Ask for price

anti- SCN9A/Nav1.7-Specific antibody
FNab07646	FN Test	100µg	EUR 702
Description: Antibody raised against SCN9A/Nav1.7-Specific

anti- Claudin 4-specific antibody
FNab01739	FN Test	100µg	EUR 606.3
Description: Antibody raised against Claudin 4-specific

anti- Claudin 9-specific antibody
FNab01741	FN Test	100µg	EUR 606.3
Description: Antibody raised against Claudin 9-specific

LDLRAD3 ORF Vector (Human) (pORF)
ORF013563	ABM	1.0 ug DNA	EUR 424.8

Ldlrad3 ORF Vector (Mouse) (pORF)
ORF049062	ABM	1.0 ug DNA	EUR 607.2

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody
20-abx134420	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody
20-abx325132	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody
abx331296-100ul	Abbexa	100 ul	EUR 510

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody
abx036874-100ug	Abbexa	100 ug	EUR 469.2

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody
20-abx014558	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

anti- fibrillin 2-Specific antibody
FNab03116	FN Test	100µg	EUR 606.3
Description: Antibody raised against fibrillin 2-Specific

Anti-Claudin 4-specific antibody
PAab01739	Lifescience Market	100 ug	EUR 426

Anti-Claudin 9-specific antibody
PAab01741	Lifescience Market	100 ug	EUR 426

Anti-SCN9A/Nav1.7-Specific antibody
PAab07646	Lifescience Market	100 ug	EUR 494.4

Anti-GAPDH (Human Specific) antibody
STJ99065	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to GAPDH (Human Specific).

Anti-Actin, muscle specific antibody
STJ190001	St John's Laboratory	200 µl	EUR 236.4
Description: Unconjugated Mouse monoclonal to Actin, muscle specific (AS1A20)

Anti-fibrillin 2-Specific antibody
PAab03116	Lifescience Market	100 ug	EUR 426

anti- Cytokeratin 1-specific antibody
FNab02211	FN Test	100µg	EUR 658.5
Description: Antibody raised against Cytokeratin 1-specific

anti- Cytokeratin 7-specific antibody
FNab02219	FN Test	100µg	EUR 658.5
Description: Antibody raised against Cytokeratin 7-specific

anti- Cytokeratin 7-specific antibody
FNab02220	FN Test	100µg	EUR 702
Description: Antibody raised against Cytokeratin 7-specific

Anti-Myeloid Specific Antigen antibody
STJ16100989	St John's Laboratory	100 µg	EUR 424.8

Anti-Myeloid Specific Antigen antibody
STJ16100158	St John's Laboratory	100 µg	EUR 466.8

Anti-Myeloid Specific Antigen antibody
STJ16100170	St John's Laboratory	100 µg	EUR 466.8

Anti-Myeloid Specific Antigen antibody
STJ16100171	St John's Laboratory	100 µg	EUR 466.8

Anti-Myeloid Specific Antigen antibody
STJ16100172	St John's Laboratory	100 µg	EUR 466.8

anti- Cytokeratin 17-Specific antibody
FNab02203	FN Test	100µg	EUR 606.3
Description: Antibody raised against Cytokeratin 17-Specific

anti- Cytokeratin 19-specific antibody
FNab02210	FN Test	100µg	EUR 702
Description: Antibody raised against Cytokeratin 19-specific

Anti-Prostate Specific Antigen antibody
STJ16100961	St John's Laboratory	1 mL	EUR 577.2

Anti-Cytokeratin 1-specific antibody
PAab02211	Lifescience Market	100 ug	EUR 463.2

Anti-Cytokeratin 7-specific antibody
PAab02219	Lifescience Market	100 ug	EUR 463.2

Anti-Cytokeratin 7-specific antibody
PAab02220	Lifescience Market	100 ug	EUR 494.4

anti- TGF-beta 2-Specific antibody
FNab08639	FN Test	100µg	EUR 658.5
Description: Antibody raised against TGF-beta 2-Specific

anti- Thrombospondin 3-Specific antibody
FNab08675	FN Test	100µg	EUR 658.5
Description: Antibody raised against Thrombospondin 3-Specific

Anti-Cytokeratin 13-Specific antibody
PAab02194	Lifescience Market	100 ug	EUR 426

Anti-Cytokeratin 17-Specific antibody
PAab02203	Lifescience Market	100 ug	EUR 426

Anti-Cytokeratin 19-specific antibody
PAab02210	Lifescience Market	100 ug	EUR 494.4

Anti-Hepatocyte Specific Antigen antibody
STJ16100376	St John's Laboratory	1 mL	EUR 954

Anti-TGF-beta 2-Specific antibody
PAab08639	Lifescience Market	100 ug	EUR 463.2

Anti-Thrombospondin 3-Specific antibody
PAab08675	Lifescience Market	100 ug	EUR 463.2

anti- smooth muscle actin specific antibody
FNab08038	FN Test	100µg	EUR 606.3
Description: Antibody raised against smooth muscle actin specific

Kv1.4-Specific Antibody
abx234664-100ug	Abbexa	100 ug	EUR 577.2

Mouse anti Human IgG (Fc Specific) antibody
10R-1908	Fitzgerald	100 ul	EUR 483.6
Description: Mouse anti Human IgG Fc fragment antibody

Mouse anti Human IgG (Fc Specific) antibody
10R-2045	Fitzgerald	100 ul	EUR 483.6
Description: Mouse anti Human IgG Fc fragment antibody

Anti-smooth muscle actin specific antibody
PAab08038	Lifescience Market	100 ug	EUR 426

Anti-Prostate Specific Antigen/KLK3 Antibody
PB9259	BosterBio	100ug/vial	EUR 352.8

Ldlrad3 3'UTR GFP Stable Cell Line
TU160981	ABM	1.0 ml	Ask for price

LDLRAD3 3'UTR GFP Stable Cell Line
TU062366	ABM	1.0 ml	EUR 1825.2

Ldlrad3 3'UTR GFP Stable Cell Line
TU257001	ABM	1.0 ml	Ask for price

TUBB3 specific antibody
PAab09890	Lifescience Market	100 ug	EUR 463.2

Ldlrad3 sgRNA CRISPR Lentivector set (Mouse)
K4550401	ABM	3 x 1.0 ug	EUR 406.8

LDLRAD3 sgRNA CRISPR Lentivector set (Human)
K1206201	ABM	3 x 1.0 ug	EUR 406.8

Rat Anti Calmodulin specific antibody ELISA kit
E02C0681-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Anti Calmodulin specific antibody ELISA kit
E02C0681-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Anti Calmodulin specific antibody ELISA kit
E02C0681-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Anti Calmodulin specific antibody ELISA kit
E08C0681-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Anti Calmodulin specific antibody ELISA kit
E08C0681-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Anti Calmodulin specific antibody ELISA kit
E08C0681-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Anti Calmodulin specific antibody ELISA kit
E07C0681-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).

 

In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.

 

Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice

 

 

STAT3 antibody
10R-2269	Fitzgerald	100 ul	EUR 483.6
Description: Mouse monoclonal STAT3 antibody

STAT3 antibody
10R-5956	Fitzgerald	100 ul	EUR 871.2
Description: Mouse monoclonal STAT3 antibody

Stat3 antibody
20R-1593	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Stat3 antibody

Stat3 antibody
20R-1597	Fitzgerald	100 ug	EUR 846
Description: Rabbit polyclonal Stat3 antibody

STAT3 antibody
20R-1911	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
20R-1912	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
20R-2227	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
20R-2228	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 Antibody
43315-100ul	SAB	100ul	EUR 302.4

STAT3 Antibody
7197-002mg	ProSci	0.02 mg	EUR 206.18
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

STAT3 Antibody
7197-01mg	ProSci	0.1 mg	EUR 523.7
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

STAT3 Antibody
BF0354	Affbiotech	200ul	EUR 540

STAT3 Antibody
AF5205	Affbiotech	200ul	EUR 420

STAT3 Antibody
AF6293	Affbiotech	200ul	EUR 420

STAT3 Antibody
AF6294	Affbiotech	200ul	EUR 420

STAT3 Antibody
AF6295	Affbiotech	200ul	EUR 420

STAT3 antibody
70R-11848	Fitzgerald	100 ug	EUR 483.6
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-13773	Fitzgerald	100 ug	EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-14315	Fitzgerald	100 ug	EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-31708	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-32513	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-32515	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-20573	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-37485	Fitzgerald	100 ug	EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody
70R-37486	Fitzgerald	100 ug	EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody
70R-51642	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50431	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50432	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50433	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-35948	Fitzgerald	100 ug	EUR 418.8
Description: Rabbit polyclonal STAT3 antibody

Stat3 Antibody
3470R-100	Biovision	each	EUR 379.2

Stat3 Antibody
3470R-30T	Biovision	each	EUR 175.2

STAT3 Antibody
48732-100ul	SAB	100ul	EUR 399.6

STAT3 Antibody
48732-50ul	SAB	50ul	EUR 286.8

Stat3 Antibody
48780-100ul	SAB	100ul	EUR 399.6

Stat3 Antibody
48780-50ul	SAB	50ul	EUR 286.8

STAT3 Antibody
ABF5205	Lifescience Market	100 ug	EUR 525.6

STAT3 Antibody
ABF6293	Lifescience Market	100 ug	EUR 525.6

STAT3 Antibody
ABF6294	Lifescience Market	100 ug	EUR 525.6

STAT3 Antibody
ABF6295	Lifescience Market	100 ug	EUR 525.6

STAT3 Antibody
1-CSB-PA050164	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

STAT3 Antibody
1-CSB-PA004173	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

STAT3 Antibody
1-CSB-PA004174	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

STAT3 Antibody
1-CSB-PA080245	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

STAT3 Antibody
1-CSB-PA022812GA01HU	Cusabio	EUR 716.40 EUR 399.60	150ul 50ul
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

STAT3 Antibody
1-CSB-PA022812LA01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000

STAT3 Antibody
F52106-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody
F52106-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody
F52120-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody
F52120-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody
F52478-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

STAT3 Antibody
F52478-0.4ML	NSJ Bioreagents	0.4 ml	EUR 330.65
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

STAT3 Antibody
F46167-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 Antibody
F47582-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 Antibody
F47582-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 Antibody
R32089	NSJ Bioreagents	100 ug	EUR 356.15
Description: The transcription factor, signal transducer and activator of transcription-3 (STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21. It contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.

STAT3 Antibody
R33329-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Signal transducer and activator of transcription 3

STAT3 Antibody
R33548-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Signal transducer and activator of transcription 3

STAT3 Antibody
V3921-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

STAT3 Antibody
V3921-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

STAT3 Antibody
V3921SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

STAT3 antibody (Ser727)
70R-32512	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody (Ser727)

STAT3 antibody (Tyr705)
70R-32514	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody (Tyr705)

STAT3 antibody (Tyr705)
70R-37126	Fitzgerald	100 ug	EUR 418.8
Description: Rabbit Polyclonal STAT3 antibody (Tyr705)

STAT3 antibody (Ser727)
70R-37127	Fitzgerald	100 ug	EUR 418.8
Description: Rabbit Polyclonal STAT3 antibody (Ser727)

Phospho STAT3 antibody
20R-2918	Fitzgerald	100 ul	EUR 471.6
Description: Rabbit polyclonal Phospho STAT3 antibody

STAT3 Antibody (pTyr705)
R20279-0.1ML	NSJ Bioreagents	100ul	EUR 347.65
Description: This recombinant phospho-Stat3 antibody reacts to human Stat3 only when phosphorylated at Tyr705. There is no cross-reactivity to Stat3 without phosphorylation at Tyr705. It may also react to mouse or rat phospho-Stat3 (Tyr705), as predicted by immunogen homology.

Polyclonal STAT3 Antibody
APR11195G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human STAT3 . This antibody is tested and proven to work in the following applications:

Polyclonal Stat3 Antibody
APR11196G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Stat3 . This antibody is tested and proven to work in the following applications:

Monoclonal STAT3 Antibody
APR11197G	Leading Biology	0.1ml	EUR 580.8
Description: A Monoclonal antibody against Human STAT3. The antibodies are raised in Mouse. This antibody is applicable in WB

Monoclonal Stat3 antibody
APR17866G	Leading Biology	0.1ml	EUR 580.8
Description: A Monoclonal antibody against Human Stat3. The antibodies are raised in Mouse. This antibody is applicable in WB

Monoclonal STAT3 Antibody
APR17867G	Leading Biology	0.1ml	EUR 580.8
Description: A Monoclonal antibody against Human STAT3. The antibodies are raised in Mouse. This antibody is applicable in WB

Recombinant STAT3 Antibody
R20477-0.1ML	NSJ Bioreagents	100ul	EUR 409

STAT3 (AcK87) Antibody
20-abx141170	Abbexa	EUR 460.80 EUR 727.20 EUR 276.00	100 ul 200 ul 30 ul

STAT3 (pY705) Antibody
20-abx133878	Abbexa	EUR 376.80 EUR 560.40 EUR 243.60	100 ul 200 ul 30 ul

STAT3 (pS727) Antibody
20-abx119323	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

STAT3 (pS727) Antibody
abx031919-400ul	Abbexa	400 ul	EUR 627.6

STAT3 (pS727) Antibody
abx031919-80l	Abbexa	80 µl	EUR 343.2

STAT3 (pY705) Antibody
abx031920-400ul	Abbexa	400 ul	EUR 627.6

STAT3 (pY705) Antibody
abx031920-80l	Abbexa	80 µl	EUR 343.2

Stat3 (pY705) Antibody
20-abx000144	Abbexa	EUR 594.00 EUR 844.80 EUR 260.40 EUR 427.20	100 ul 200 ul 20 ul 50 ul

STAT3 (pS727) Antibody
20-abx000188	Abbexa	EUR 594.00 EUR 844.80 EUR 427.20	100 ul 200 ul 50 ul

STAT3 (pS727) Antibody
20-abx009767	Abbexa	EUR 376.80 EUR 560.40 EUR 243.60	100 ul 200 ul 30 ul

STAT3 (pY705) Antibody
abx011825-100ug	Abbexa	100 ug	EUR 526.8