Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.
A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.
Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.
Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.
Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.
The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.
The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.
Mdm2 promotes systemic lupus erythematosus and lupus nephritis.
Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.
To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.
Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.
Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.
LDLRAD3 Antibody |
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1-CSB-PA007326 | Cusabio |
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Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000 |
LDLRAD3 Antibody |
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E11-16505C | EnoGene | 100μg | EUR 225 |
Description: Available in various conjugation types. |
LDLRAD3 Antibody |
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E034765 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
LDLRAD3 Antibody |
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8C16505 | AAT Bioquest | 50ug | EUR 368 |
Description: LDLRAD3 Antibody |
LDLRAD3 Antibody |
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E38PA3456 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
LDLRAD3 Antibody |
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E306476 | EnoGene | 100μg/200μl | EUR 275 |
Description: Available in various conjugation types. |
LDLRAD3 Conjugated Antibody |
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C34765 | SAB | 100ul | EUR 476.4 |
LDLRAD3 Polyclonal Antibody |
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ABP53840-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
LDLRAD3 Polyclonal Antibody |
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ABP53840-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
LDLRAD3 Polyclonal Antibody |
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ABP53840-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
LDLRAD3 Polyclonal Antibody |
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ES4839-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA |
LDLRAD3 Polyclonal Antibody |
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ES4839-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA |
LDLRAD3 Polyclonal Antibody |
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E20-72551 | EnoGene | 100ug | EUR 225 |
Description: Available in various conjugation types. |
OAAF03797-100UG - LDLRAD3 Antibody |
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OAAF03797-100UG | Aviva Systems Biology | 100ug | EUR 329 |
Polyclonal LDLRAD3 antibody - middle region |
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APR01194G | Leading Biology | 0.05mg | EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications: |
ARP53301_P050-25UL - LDLRAD3 Antibody - middle region |
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ARP53301_P050-25UL | Aviva Systems Biology | 25ul | EUR 99 |
ARP53301_P050 - LDLRAD3 antibody - middle region (ARP53301_P050) |
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ARP53301_P050 | Aviva Systems Biology | 100ul | EUR 389 |
LDLRAD3 (C-term) rabbit polyclonal antibody, Aff - Purified |
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AP52462PU-N | Origene Technologies GmbH | 400 µl | Ask for price |
LDLRAD3 siRNA |
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20-abx922395 | Abbexa |
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LDLRAD3 siRNA |
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20-abx922396 | Abbexa |
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LDLRAD3 cloning plasmid |
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CSB-CL803154HU-10ug | Cusabio | 10ug | EUR 481.2 |
Description: A cloning plasmid for the LDLRAD3 gene. |
LDLRAD3 Blocking Peptide |
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33R-1897 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224 |
LDLRAD3 Blocking Peptide |
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20-abx162318 | Abbexa |
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Mouse Ldlrad3 ELISA KIT |
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ELI-27814m | Lifescience Market | 96 Tests | EUR 1038 |
Human LDLRAD3 ELISA KIT |
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ELI-39778h | Lifescience Market | 96 Tests | EUR 988.8 |
Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody |
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20-abx134420 | Abbexa |
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Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody |
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20-abx325132 | Abbexa |
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Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody |
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abx331296-100ul | Abbexa | 100 ul | EUR 510 |
Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody |
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abx036874-100ug | Abbexa | 100 ug | EUR 469.2 |
Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody |
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20-abx014558 | Abbexa |
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anti- LDLRAD1 antibody |
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FNab04743 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against LDLRAD1 |
Human LDLRAD3 shRNA Plasmid |
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20-abx965371 | Abbexa |
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Mouse LDLRAD3 shRNA Plasmid |
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20-abx982528 | Abbexa |
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LDLRAD3 Recombinant Protein (Mouse) |
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RP147182 | ABM | 100 ug | Ask for price |
LDLRAD3 Recombinant Protein (Human) |
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RP040687 | ABM | 100 ug | Ask for price |
LDLRAD3 ORF Vector (Human) (pORF) |
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ORF013563 | ABM | 1.0 ug DNA | EUR 424.8 |
Ldlrad3 ORF Vector (Mouse) (pORF) |
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ORF049062 | ABM | 1.0 ug DNA | EUR 607.2 |
LDLRAD3 (untagged)-Human low density lipoprotein receptor class A domain containing 3 (LDLRAD3) |
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SC313048 | Origene Technologies GmbH | 10 µg | Ask for price |
Human LDLRAD3 knockout cell line |
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ABC-KH8368 | AcceGen | 1 vial | Ask for price |
Description: Human LDLRAD3 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology. |
Human LDLRAD3 knockdown cell line |
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ABC-KD8368 | AcceGen | 1 vial | Ask for price |
Description: Human LDLRAD3 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest. |
Human LDLRAD3 Protein Lysate 20ug |
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IHULDLRAD3PLLY20UG | Innovative research | each | EUR 213 |
Description: Human LDLRAD3 Protein Lysate 20ug |
Ldlrad3 (untagged) - Mouse low density lipoprotein receptor class A domain containing 3 (Ldlrad3), (10ug) |
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MC213129 | Origene Technologies GmbH | 10 µg | Ask for price |
LDLRAD3 (GFP-tagged) - Human low density lipoprotein receptor class A domain containing 3 (LDLRAD3) |
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RG207286 | Origene Technologies GmbH | 10 µg | Ask for price |
anti- Kv1.4-Specific antibody |
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FNab04664 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Kv1.4-Specific |
anti- TDRKH specific antibody |
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FNab08580 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against TDRKH specific |
anti- TUBB3 specific antibody |
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FNab09890 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against TUBB3 specific |
anti- REDD1 specific antibody |
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FNab07228 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against REDD1 specific |
Anti-Kv1.4-Specific antibody |
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PAab04664 | Lifescience Market | 100 ug | EUR 426 |
Ldlrad3 (GFP-tagged) - Mouse low density lipoprotein receptor class A domain containing 3 (Ldlrad3), (10ug) |
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MG217397 | Origene Technologies GmbH | 10 µg | Ask for price |
LDLRAD3 (Myc-DDK-tagged)-Human low density lipoprotein receptor class A domain containing 3 (LDLRAD3) |
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RC207286 | Origene Technologies GmbH | 10 µg | Ask for price |
Ldlrad3 (Myc-DDK-tagged) - Mouse low density lipoprotein receptor class A domain containing 3 (Ldlrad3) |
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MR217397 | Origene Technologies GmbH | 10 µg | Ask for price |
Anti-REDD1 specific antibody |
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PAab07228 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-TDRKH specific antibody |
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PAab08580 | Lifescience Market | 100 ug | EUR 463.2 |
OCOA04994-20UG - LDLRAD3 Protein Lysate |
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OCOA04994-20UG | Aviva Systems Biology | 20ug | EUR 169 |
Ldlrad3 3'UTR GFP Stable Cell Line |
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TU257001 | ABM | 1.0 ml | Ask for price |
Ldlrad3 3'UTR GFP Stable Cell Line |
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TU160981 | ABM | 1.0 ml | Ask for price |
LDLRAD3 3'UTR GFP Stable Cell Line |
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TU062366 | ABM | 1.0 ml | EUR 1825.2 |
Ldlrad3 sgRNA CRISPR Lentivector set (Mouse) |
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K4550401 | ABM | 3 x 1.0 ug | EUR 406.8 |
LDLRAD3 sgRNA CRISPR Lentivector set (Human) |
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K1206201 | ABM | 3 x 1.0 ug | EUR 406.8 |
anti- SCN9A/Nav1.7-Specific antibody |
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FNab07646 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against SCN9A/Nav1.7-Specific |
anti- Claudin 4-specific antibody |
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FNab01739 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Claudin 4-specific |
anti- Claudin 9-specific antibody |
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FNab01741 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Claudin 9-specific |
Ldlrad3 (untagged) - Mouse low density lipoprotein receptor class A domain containing 3 (Ldlrad3), transcript variant 2 |
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MC227167 | Origene Technologies GmbH | 10 µg | Ask for price |
anti- fibrillin 2-Specific antibody |
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FNab03116 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against fibrillin 2-Specific |
Anti-Claudin 4-specific antibody |
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PAab01739 | Lifescience Market | 100 ug | EUR 426 |
Anti-Claudin 9-specific antibody |
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PAab01741 | Lifescience Market | 100 ug | EUR 426 |
Anti-SCN9A/Nav1.7-Specific antibody |
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PAab07646 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-GAPDH (Human Specific) antibody |
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STJ99065 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to GAPDH (Human Specific). |
LDLRAD3 Protein Vector (Mouse) (pPM-C-HA) |
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PV196248 | ABM | 500 ng | EUR 723.6 |
LDLRAD3 Protein Vector (Human) (pPM-C-HA) |
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PV054251 | ABM | 500 ng | EUR 577.2 |
Anti-Actin, muscle specific antibody |
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STJ190001 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Mouse monoclonal to Actin, muscle specific (AS1A20) |
LDLRAD3 Protein Vector (Mouse) (pPB-C-His) |
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PV196246 | ABM | 500 ng | EUR 723.6 |
LDLRAD3 Protein Vector (Mouse) (pPB-N-His) |
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PV196247 | ABM | 500 ng | EUR 723.6 |
LDLRAD3 Protein Vector (Mouse) (pPM-C-His) |
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PV196249 | ABM | 500 ng | EUR 723.6 |
LDLRAD3 Protein Vector (Human) (pPB-C-His) |
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PV054249 | ABM | 500 ng | EUR 577.2 |
LDLRAD3 Protein Vector (Human) (pPB-N-His) |
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PV054250 | ABM | 500 ng | EUR 577.2 |
LDLRAD3 Protein Vector (Human) (pPM-C-His) |
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PV054252 | ABM | 500 ng | EUR 577.2 |
Ldlrad3 3'UTR Luciferase Stable Cell Line |
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TU110981 | ABM | 1.0 ml | Ask for price |
Ldlrad3 3'UTR Luciferase Stable Cell Line |
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TU207001 | ABM | 1.0 ml | Ask for price |
LDLRAD3 3'UTR Luciferase Stable Cell Line |
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TU012366 | ABM | 1.0 ml | EUR 1825.2 |
AAP53301-100UG - LDLRAD3 Peptide - middle region |
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AAP53301-100UG | Aviva Systems Biology | 100ug | EUR 99 |
Anti-fibrillin 2-Specific antibody |
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PAab03116 | Lifescience Market | 100 ug | EUR 426 |
anti- Cytokeratin 1-specific antibody |
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FNab02211 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against Cytokeratin 1-specific |
anti- Cytokeratin 7-specific antibody |
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FNab02219 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against Cytokeratin 7-specific |
anti- Cytokeratin 7-specific antibody |
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FNab02220 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Cytokeratin 7-specific |
Anti-Myeloid Specific Antigen antibody |
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STJ16100989 | St John's Laboratory | 100 µg | EUR 424.8 |
Anti-Myeloid Specific Antigen antibody |
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STJ16100158 | St John's Laboratory | 100 µg | EUR 466.8 |
p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.
The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).
In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.
Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice
STAT3 antibody |
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10R-5956 | Fitzgerald | 100 ul | EUR 871.2 |
Description: Mouse monoclonal STAT3 antibody |
Stat3 antibody |
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20R-1593 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal Stat3 antibody |
Stat3 antibody |
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20R-1597 | Fitzgerald | 100 ug | EUR 846 |
Description: Rabbit polyclonal Stat3 antibody |
STAT3 antibody |
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20R-1911 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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20R-1912 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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20R-2227 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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20R-2228 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 Antibody |
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43315-100ul | SAB | 100ul | EUR 302.4 |
STAT3 Antibody |
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7197-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system. |
STAT3 Antibody |
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7197-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system. |
STAT3 antibody |
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70R-11848 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-13773 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Affinity purified Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-14315 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Affinity purified Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-31708 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-32513 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-32515 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-20573 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-37485 | Fitzgerald | 100 ug | EUR 327.6 |
Description: Rabbit Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-37486 | Fitzgerald | 100 ug | EUR 327.6 |
Description: Rabbit Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-51642 | Fitzgerald | 100 ul | EUR 344.4 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-50431 | Fitzgerald | 100 ul | EUR 344.4 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-50432 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-50433 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-35948 | Fitzgerald | 100 ug | EUR 418.8 |
Description: Rabbit polyclonal STAT3 antibody |
Stat3 Antibody |
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3470R-100 | Biovision | each | EUR 379.2 |
Stat3 Antibody |
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3470R-30T | Biovision | each | EUR 175.2 |
STAT3 Antibody |
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48732-100ul | SAB | 100ul | EUR 399.6 |
STAT3 Antibody |
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48732-50ul | SAB | 50ul | EUR 286.8 |
Stat3 Antibody |
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48780-100ul | SAB | 100ul | EUR 399.6 |
Stat3 Antibody |
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48780-50ul | SAB | 50ul | EUR 286.8 |
STAT3 Antibody |
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ABF5205 | Lifescience Market | 100 ug | EUR 525.6 |
STAT3 Antibody |
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ABF6293 | Lifescience Market | 100 ug | EUR 525.6 |
STAT3 Antibody |
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ABF6294 | Lifescience Market | 100 ug | EUR 525.6 |
STAT3 Antibody |
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ABF6295 | Lifescience Market | 100 ug | EUR 525.6 |
STAT3 Antibody |
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1-CSB-PA050164 | Cusabio |
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Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000 |
STAT3 Antibody |
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1-CSB-PA004173 | Cusabio |
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Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000 |
STAT3 Antibody |
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1-CSB-PA004174 | Cusabio |
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Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000 |
STAT3 Antibody |
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1-CSB-PA080245 | Cusabio |
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Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500 |
STAT3 Antibody |
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1-CSB-PA022812GA01HU | Cusabio |
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Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
STAT3 Antibody |
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1-CSB-PA022812LA01HU | Cusabio |
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Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000 |
STAT3 Antibody |
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F52106-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. |
STAT3 Antibody |
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F52106-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. |
STAT3 Antibody |
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F52120-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. |
STAT3 Antibody |
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F52120-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. |
STAT3 Antibody |
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F52478-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). |
STAT3 Antibody |
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F52478-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 330.65 |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). |
STAT3 Antibody |
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F46167-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
STAT3 Antibody |
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F47582-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
STAT3 Antibody |
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F47582-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
STAT3 Antibody |
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AF7800 | Affinity Biosciences | 100ul | EUR 350 |
Description: Human,Mouse,Rat |
STAT3 Antibody |
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BF0354 | Affinity Biosciences | 100ul | EUR 350 |
Description: Human,Mouse,Rat,Monkey |
STAT3 Antibody |
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AF5205 | Affinity Biosciences | 100ul | EUR 280 |
Description: Human,Mouse,Rat |
STAT3 Antibody |
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AF6293 | Affinity Biosciences | 100ul | EUR 280 |
Description: Human,Mouse,Rat |
STAT3 Antibody |
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AF6294 | Affinity Biosciences | 100ul | EUR 280 |
Description: Human,Mouse,Rat |
STAT3 Antibody |
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AF6295 | Affinity Biosciences | 100ul | EUR 280 |
Description: Human,Mouse,Rat,Monkey |
STAT3 Antibody |
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8C10589 | AAT Bioquest | 50ug | EUR 368 |
Description: STAT3 Antibody |
STAT3 Antibody |
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R32089 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: The transcription factor, signal transducer and activator of transcription-3 (STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21. It contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus. |
STAT3 Antibody |
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R33329-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Signal transducer and activator of transcription 3 |
STAT3 Antibody |
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R33548-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Signal transducer and activator of transcription 3 |
STAT3 Antibody |
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V3921-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. |
STAT3 Antibody |
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V3921-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. |
STAT3 Antibody |
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V3921SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. |
STAT3 antibody |
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CAF50341-100ug | Biomatik Corporation | 100ug | EUR 338 |
STAT3 Antibody |
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CAC08876-100ug | Biomatik Corporation | 100ug | EUR 314 |
STAT3 Antibody |
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CAC08876-50ug | Biomatik Corporation | 50ug | EUR 199.2 |
STAT3 Antibody |
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E11-10589C | EnoGene | 100μg | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E043315 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E10-20293 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E10-30122 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E2310003 | EnoGene | 100ug | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E301845 | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E301873b | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E301930 | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E301930b | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E306329 | EnoGene | 100μg/200μl | EUR 275 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E313513 | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E38PA9213 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E38PA9214 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E38PA2113 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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E38PA2114 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
STAT3 Antibody |
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AF7800-100ul | Affinity Biosciences | 100ul | EUR 350 |
STAT3 Antibody |
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AF7800-200ul | Affinity Biosciences | 200ul | EUR 450 |
STAT3 Antibody |
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AF7800-50ul | Affinity Biosciences | 50ul | EUR 250 |
STAT3 Antibody |
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AF5205-100ul | Affinity Biosciences | 100ul | EUR 280 |
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