Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.
A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.
Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.
Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.
Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.
The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.
The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.
Mdm2 promotes systemic lupus erythematosus and lupus nephritis.
Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.
To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.
Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.
Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

LDLRAD3 Antibody |
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CSB-PA786511- | Cusabio | EUR 402 | |
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500 |
LDLRAD3 Antibody |
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CSB-PA786511-100ul | Cusabio | 100ul | EUR 379.2 |
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500 |
LDLRAD3 Antibody |
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1-CSB-PA007326 | Cusabio |
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Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000 |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
LDLRAD3 Polyclonal Antibody |
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ABP53840-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
LDLRAD3 Polyclonal Antibody |
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ABP53840-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
LDLRAD3 Polyclonal Antibody |
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ABP53840-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
LDLRAD3 Conjugated Antibody |
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C34765 | SAB | 100ul | EUR 476.4 |
LDLRAD3 Polyclonal Antibody |
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ES4839-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA |
LDLRAD3 Polyclonal Antibody |
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ES4839-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA |
LDLRAD3 siRNA |
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20-abx922395 | Abbexa |
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LDLRAD3 siRNA |
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20-abx922396 | Abbexa |
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LDLRAD3 Blocking Peptide |
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33R-1897 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224 |
LDLRAD3 Blocking Peptide |
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20-abx162318 | Abbexa |
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LDLRAD3 cloning plasmid |
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CSB-CL803154HU-10ug | Cusabio | 10ug | EUR 481.2 |
Description: A cloning plasmid for the LDLRAD3 gene. |
Polyclonal LDLRAD3 antibody - middle region |
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APR01194G | Leading Biology | 0.05mg | EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications: |
Human LDLRAD3 shRNA Plasmid |
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20-abx965371 | Abbexa |
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Mouse LDLRAD3 shRNA Plasmid |
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20-abx982528 | Abbexa |
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Human LDLRAD3 ELISA KIT |
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ELI-39778h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse Ldlrad3 ELISA KIT |
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ELI-27814m | Lifescience Market | 96 Tests | EUR 1038 |
LDLRAD3 Recombinant Protein (Human) |
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RP040687 | ABM | 100 ug | Ask for price |
LDLRAD3 Recombinant Protein (Mouse) |
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RP147182 | ABM | 100 ug | Ask for price |
Polyclonal Goat anti-GST α-form |
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GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
Anti-ACADL-Specific antibody |
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PAab00064 | Lifescience Market | 100 ug | EUR 426 |
Anti-ACTA1-Specific antibody |
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PAab00115 | Lifescience Market | 100 ug | EUR 426 |
Anti-ADAM17-Specific antibody |
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PAab00139 | Lifescience Market | 100 ug | EUR 426 |
Anti-ADRA1A-Specific antibody |
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PAab00177 | Lifescience Market | 100 ug | EUR 426 |
Anti-ADRA2B-Specific antibody |
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PAab00179 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-AFF1-Specific antibody |
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PAab00195 | Lifescience Market | 100 ug | EUR 426 |
Anti-AKAP11-Specific antibody |
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PAab00251 | Lifescience Market | 100 ug | EUR 426 |
Anti-AMPD1-Specific antibody |
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PAab00370 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-ARF5-Specific antibody |
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PAab00534 | Lifescience Market | 100 ug | EUR 426 |
Anti-ARF6-Specific antibody |
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PAab00535 | Lifescience Market | 100 ug | EUR 426 |
Anti-ARHGEF9-Specific antibody |
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PAab00565 | Lifescience Market | 100 ug | EUR 426 |
Anti-ARSK-Specific antibody |
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PAab00613 | Lifescience Market | 100 ug | EUR 426 |
Anti-ATF2-Specific antibody |
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PAab00661 | Lifescience Market | 100 ug | EUR 426 |
Anti-ATP1A1-Specific antibody |
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PAab00692 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-ATP1A2-Specific antibody |
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PAab00694 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-ATP5G2-Specific antibody |
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PAab00708 | Lifescience Market | 100 ug | EUR 426 |
Anti-BAG1S-specific antibody |
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PAab00788 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-BAI2-Specific antibody |
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PAab00791 | Lifescience Market | 100 ug | EUR 426 |
Anti-BAI3-Specific antibody |
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PAab00792 | Lifescience Market | 100 ug | EUR 426 |
Anti-Barkor-Specific antibody |
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PAab00806 | Lifescience Market | 100 ug | EUR 426 |
Anti-BLOC1S1-Specific antibody |
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PAab00909 | Lifescience Market | 100 ug | EUR 426 |
Anti-BRN2-Specific antibody |
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PAab00963 | Lifescience Market | 100 ug | EUR 426 |
Anti-BTF3L3-Specific antibody |
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PAab00976 | Lifescience Market | 100 ug | EUR 426 |
Anti-SLC12A5-Specific antibody |
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PAab07908 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SLC25A6-Specific antibody |
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PAab07947 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SLIT2-Specific antibody |
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PAab07981 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SMYD1-Specific antibody |
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PAab08047 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-Somatostatin-Specific antibody |
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PAab08109 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SPAG4-Specific antibody |
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PAab08142 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SPIN1-Specific antibody |
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PAab08178 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-SPTBN1-Specific antibody |
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PAab08204 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SRGAP3-Specific antibody |
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PAab08227 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-ST8SIA2-Specific antibody |
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PAab08276 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-STEAP2-Specific antibody |
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PAab08317 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-SURVIVIN-Specific antibody |
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PAab08403 | Lifescience Market | 100 ug | EUR 426 |
Anti-SYN1-Specific antibody |
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PAab08416 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-TAF1-Specific antibody |
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PAab08484 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-TDRKH specific antibody |
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PAab08580 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-TGFBR3-Specific antibody |
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PAab08645 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-TINAG-Specific antibody |
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PAab08712 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-TMF1-Specific antibody |
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PAab08796 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-TOP2A-Specific antibody |
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PAab08868 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-Tuberin-Specific antibody |
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PAab09101 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-TWIST1-specific antibody |
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PAab09118 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-UBASH3A-Specific antibody |
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PAab09150 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-UBC9-Specific antibody |
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PAab09159 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-UBE2D1-Specific antibody |
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PAab09167 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-UBN1-Specific antibody |
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PAab09202 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-UNC5C-Specific antibody |
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PAab09263 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-UNC5D-Specific antibody |
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PAab09264 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-URB1-Specific antibody |
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PAab09286 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-WASF4-Specific antibody |
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PAab09469 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-YES1-Specific antibody |
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PAab09563 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-ZIC4-Specific antibody |
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PAab09637 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-ZNF600-Specific antibody |
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PAab09718 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-ZNRF2-Specific antibody |
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PAab09746 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-CAPG-Specific antibody |
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PAab01249 | Lifescience Market | 100 ug | EUR 426 |
Anti-Catalase-Specific antibody |
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PAab01302 | Lifescience Market | 100 ug | EUR 426 |
Anti-CCKAR-specific antibody |
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PAab01377 | Lifescience Market | 100 ug | EUR 426 |
Anti-CCKBR-specific antibody |
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PAab01378 | Lifescience Market | 100 ug | EUR 426 |
Anti-CCR2-specific antibody |
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PAab01390 | Lifescience Market | 100 ug | EUR 426 |
Anti-CCT6A-Specific antibody |
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PAab01401 | Lifescience Market | 100 ug | EUR 426 |
p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.
The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).
In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.
Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice
anti- STAT3 antibody |
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FNab08300 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against STAT3 |
Anti-STAT3 Antibody |
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PA1108 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-STAT3 Antibody |
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PA1778 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-STAT3 Antibody |
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PB9511 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-STAT3 antibody |
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STJ113436 | St John's Laboratory | 50 µl | EUR 344.4 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-STAT3 antibody |
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STJ113737 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-STAT3 antibody |
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STJ118189 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-STAT3 antibody |
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STJ119281 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-Stat3 antibody |
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STJ98399 | St John's Laboratory | 100 µl | EUR 280.8 |
Description: Mouse monoclonal to Stat3. |
Anti-Stat3 antibody |
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STJ98400 | St John's Laboratory | 100 µl | EUR 280.8 |
Description: Mouse monoclonal to Stat3. |
Anti-STAT3 antibody |
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STJ99212 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to STAT3. |
Anti-Stat3 antibody |
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STJ95808 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ95808 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Stat3 protein. |
Anti-Stat3 antibody |
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STJ95809 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Stat3. |
Anti-Stat3 antibody |
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STJ95810 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Stat3. |
Anti-Stat3 antibody |
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STJ97467 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Stat3. |
Anti-Stat3 antibody |
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STJ97468 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Stat3. |
Anti-STAT3 antibody |
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STJ97520 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to STAT3 (1E3). |
Anti-STAT3 antibody |
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STJ97525 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to STAT3 (3F4). |
Anti-STAT3 antibody |
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STJ29841 | St John's Laboratory | 100 µl | EUR 495.6 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-STAT3 antibody |
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STJ27462 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-STAT3 Antibody |
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STJ503137 | St John's Laboratory | 100 µg | EUR 571.2 |
Anti-STAT3 antibody |
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STJ70982 | St John's Laboratory | 100 µg | EUR 430.8 |
anti-STAT3 |
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YF-PA14814 | Abfrontier | 50 ug | EUR 435.6 |
Description: Mouse polyclonal to STAT3 |
Anti-Phospho-STAT3 Antibody |
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STJ502696 | St John's Laboratory | 100 µg | EUR 703.2 |
Anti-STAT3 Antibody (Biotin) |
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STJ503138 | St John's Laboratory | 100 µg | EUR 703.2 |
Anti-STAT3 Antibody (FITC) |
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STJ503139 | St John's Laboratory | 100 µg | EUR 703.2 |
anti-STAT3 (3B5) |
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LF-MA30485 | Abfrontier | 100 ul | EUR 583.2 |
Description: Mouse Monoclonal to STAT3 |
anti-STAT3 (7G3H4) |
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LF-MA30243 | Abfrontier | 100 ul | EUR 583.2 |
Description: Mouse Monoclonal to STAT3 |
Anti-STAT3 (4D6) |
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YF-MA10886 | Abfrontier | 100 ug | EUR 435.6 |
Description: Mouse monoclonal to STAT3 |
Polyclonal Goat Anti-STAT3 Antibody |
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APG00319G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STAT3 . This antibody is tested and proven to work in the following applications: |
Anti-STAT3 Rabbit Monoclonal Antibody |
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M00007 | BosterBio | 100ug/vial | EUR 476.4 |
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
Anti-STAT3 Rabbit Monoclonal Antibody |
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M00007-1 | BosterBio | 100ug/vial | EUR 476.4 |
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
Anti-STAT3 Rabbit Monoclonal Antibody |
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M00007-2 | BosterBio | 100ug/vial | EUR 476.4 |
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IP, IF, WB and tested in Human. |
Anti-Phospho-STAT3-(S727) antibody |
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STJ116371 | St John's Laboratory | 100 µl | EUR 471.6 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-Stat3 (Acetyl Lys87) antibody |
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STJ97699 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Stat3 (Acetyl Lys87). |
Anti-Phospho-Stat3 (Y705) antibody |
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STJ97747 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to Phospho-Stat3 (Y705). |
Anti-Phospho-STAT3-(Y705) antibody |
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STJ27511 | St John's Laboratory | 100 µl | EUR 471.6 |
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Anti-Phospho-Stat3 (S727) antibody |
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STJ90410 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90410 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about S727 when S727 is phosphorylated. |
Anti-Phospho-Stat3 (Y705) antibody |
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STJ90411 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about Y705 when Y705 is phosphorylated. |
Anti-Phospho-STAT3 Antibody BIOTIN |
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STJ502697 | St John's Laboratory | 100 µg | EUR 774 |
Anti-Phospho-STAT3 Antibody FITC |
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STJ502698 | St John's Laboratory | 100 µg | EUR 774 |
Anti-Stat3 (Acetyl-Lys49) Antibody |
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STJ193228 | St John's Laboratory | 200 µl | EUR 236.4 |
Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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DLR-STAT3-Hu-48T | DL Develop | 48T | EUR 597.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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DLR-STAT3-Hu-96T | DL Develop | 96T | EUR 776.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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DLR-STAT3-Mu-48T | DL Develop | 48T | EUR 609.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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DLR-STAT3-Mu-96T | DL Develop | 96T | EUR 793.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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DLR-STAT3-Ra-48T | DL Develop | 48T | EUR 633.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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DLR-STAT3-Ra-96T | DL Develop | 96T | EUR 828 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RD-STAT3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RD-STAT3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RD-STAT3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RD-STAT3-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RD-STAT3-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RD-STAT3-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RDR-STAT3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 626.4 |
Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RDR-STAT3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 868.8 |
Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RDR-STAT3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RDR-STAT3-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RDR-STAT3-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 669.6 |
Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit |
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RDR-STAT3-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 931.2 |
STAT3 antibody |
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70R-11848 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 Antibody |
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43315-100ul | SAB | 100ul | EUR 302.4 |
STAT3 antibody |
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70R-37485 | Fitzgerald | 100 ug | EUR 327.6 |
Description: Rabbit Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-37486 | Fitzgerald | 100 ug | EUR 327.6 |
Description: Rabbit Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-50431 | Fitzgerald | 100 ul | EUR 344.4 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-50432 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-50433 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-20573 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-35948 | Fitzgerald | 100 ug | EUR 418.8 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-31708 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-32513 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-32515 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-14315 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Affinity purified Rabbit polyclonal STAT3 antibody |
STAT3 antibody |
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70R-51642 | Fitzgerald | 100 ul | EUR 344.4 |
Description: Purified Polyclonal STAT3 antibody |
STAT3 antibody |
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70R-13773 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Affinity purified Rabbit polyclonal STAT3 antibody |
STAT3 Antibody |
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48732-100ul | SAB | 100ul | EUR 399.6 |
STAT3 Antibody |
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48732-50ul | SAB | 50ul | EUR 286.8 |
Stat3 Antibody |
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48780-100ul | SAB | 100ul | EUR 399.6 |
Stat3 Antibody |
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48780-50ul | SAB | 50ul | EUR 286.8 |
Stat3 Antibody |
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3470R-100 | Biovision | EUR 379.2 |
Stat3 Antibody |
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3470R-30T | Biovision | EUR 175.2 |
STAT3 antibody |
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10R-5956 | Fitzgerald | 100 ul | EUR 871.2 |
Description: Mouse monoclonal STAT3 antibody |
STAT3 antibody |
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10R-1224 | Fitzgerald | 100 ug | EUR 614.4 |
Description: Mouse monoclonal STAT3 antibody |
Stat3 antibody |
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20R-1593 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal Stat3 antibody |
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