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Posted inAntibodies Assay Kits Biology Cells cDNA Clia Kits Culture Cells Devices DNA DNA Templates Elisa Kits Enzymes Equipments Exosomes Gels Isotypes Medium & Serums NATtrol Panel Particles PCR Pcr Kits Peptides Reagents Recombinant Proteins Ria Kits RNA Test Kits Vector & Virus Western Blot

Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

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Posted By Martin Posted on August 22, 2020
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Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.

 

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.

Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.

Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.

 

The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.

 

The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.

 

 

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.

To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.

 

Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.

 

Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

chipgrade
chipgrade

LDLRAD3 Antibody

1-CSB-PA007326 Cusabio
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000

LDLRAD3 Conjugated Antibody

C34765 SAB 100ul
EUR 476.4

LDLRAD3 Polyclonal Antibody

ABP53840-003ml Abbkine 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody

ABP53840-01ml Abbkine 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody

ABP53840-02ml Abbkine 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody

ES4839-100ul ELK Biotech 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody

ES4839-50ul ELK Biotech 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

Polyclonal LDLRAD3 antibody - middle region

APR01194G Leading Biology 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications:

LDLRAD3 siRNA

20-abx922395 Abbexa
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

LDLRAD3 siRNA

20-abx922396 Abbexa
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

LDLRAD3 cloning plasmid

CSB-CL803154HU-10ug Cusabio 10ug
EUR 481.2
Description: A cloning plasmid for the LDLRAD3 gene.

LDLRAD3 Blocking Peptide

33R-1897 Fitzgerald 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224

LDLRAD3 Blocking Peptide

20-abx162318 Abbexa
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

anti- Kv1.4-Specific antibody

FNab04664 FN Test 100µg
EUR 606.3
Description: Antibody raised against Kv1.4-Specific

anti- TDRKH specific antibody

FNab08580 FN Test 100µg
EUR 658.5
Description: Antibody raised against TDRKH specific

anti- TUBB3 specific antibody

FNab09890 FN Test 100µg
EUR 658.5
Description: Antibody raised against TUBB3 specific

anti- REDD1 specific antibody

FNab07228 FN Test 100µg
EUR 658.5
Description: Antibody raised against REDD1 specific

Mouse Ldlrad3 ELISA KIT

ELI-27814m Lifescience Market 96 Tests
EUR 1038

Human LDLRAD3 ELISA KIT

ELI-39778h Lifescience Market 96 Tests
EUR 988.8

Anti-Kv1.4-Specific antibody

PAab04664 Lifescience Market 100 ug
EUR 426

Anti-REDD1 specific antibody

PAab07228 Lifescience Market 100 ug
EUR 463.2

Anti-TDRKH specific antibody

PAab08580 Lifescience Market 100 ug
EUR 463.2

Human LDLRAD3 shRNA Plasmid

20-abx965371 Abbexa
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse LDLRAD3 shRNA Plasmid

20-abx982528 Abbexa
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

anti- LDLRAD1 antibody

FNab04743 FN Test 100µg
EUR 658.5
Description: Antibody raised against LDLRAD1

TDRKH Specific (TDRKH specific) Antibody

abx238580-100ug Abbexa 100 ug
EUR 610.8

REDD1 Specific (REDD1 specific) Antibody

abx237228-100ug Abbexa 100 ug
EUR 610.8

LDLRAD3 Recombinant Protein (Mouse)

RP147182 ABM 100 ug Ask for price

LDLRAD3 Recombinant Protein (Human)

RP040687 ABM 100 ug Ask for price

anti- SCN9A/Nav1.7-Specific antibody

FNab07646 FN Test 100µg
EUR 702
Description: Antibody raised against SCN9A/Nav1.7-Specific

anti- Claudin 4-specific antibody

FNab01739 FN Test 100µg
EUR 606.3
Description: Antibody raised against Claudin 4-specific

anti- Claudin 9-specific antibody

FNab01741 FN Test 100µg
EUR 606.3
Description: Antibody raised against Claudin 9-specific

LDLRAD3 ORF Vector (Human) (pORF)

ORF013563 ABM 1.0 ug DNA
EUR 424.8

Ldlrad3 ORF Vector (Mouse) (pORF)

ORF049062 ABM 1.0 ug DNA
EUR 607.2

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody

20-abx134420 Abbexa
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody

20-abx325132 Abbexa
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody

abx331296-100ul Abbexa 100 ul
EUR 510

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody

abx036874-100ug Abbexa 100 ug
EUR 469.2

Low Density Lipoprotein Receptor Class A Domain Containing 3 (LDLRAD3) Antibody

20-abx014558 Abbexa
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

anti- fibrillin 2-Specific antibody

FNab03116 FN Test 100µg
EUR 606.3
Description: Antibody raised against fibrillin 2-Specific

Anti-Claudin 4-specific antibody

PAab01739 Lifescience Market 100 ug
EUR 426

Anti-Claudin 9-specific antibody

PAab01741 Lifescience Market 100 ug
EUR 426

Anti-SCN9A/Nav1.7-Specific antibody

PAab07646 Lifescience Market 100 ug
EUR 494.4

Anti-GAPDH (Human Specific) antibody

STJ99065 St John's Laboratory 200 µl
EUR 236.4
Description: Mouse monoclonal to GAPDH (Human Specific).

Anti-Actin, muscle specific antibody

STJ190001 St John's Laboratory 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to Actin, muscle specific (AS1A20)

Anti-fibrillin 2-Specific antibody

PAab03116 Lifescience Market 100 ug
EUR 426

anti- Cytokeratin 1-specific antibody

FNab02211 FN Test 100µg
EUR 658.5
Description: Antibody raised against Cytokeratin 1-specific

anti- Cytokeratin 7-specific antibody

FNab02219 FN Test 100µg
EUR 658.5
Description: Antibody raised against Cytokeratin 7-specific

anti- Cytokeratin 7-specific antibody

FNab02220 FN Test 100µg
EUR 702
Description: Antibody raised against Cytokeratin 7-specific

Anti-Myeloid Specific Antigen antibody

STJ16100989 St John's Laboratory 100 µg
EUR 424.8

Anti-Myeloid Specific Antigen antibody

STJ16100158 St John's Laboratory 100 µg
EUR 466.8

Anti-Myeloid Specific Antigen antibody

STJ16100170 St John's Laboratory 100 µg
EUR 466.8

Anti-Myeloid Specific Antigen antibody

STJ16100171 St John's Laboratory 100 µg
EUR 466.8

Anti-Myeloid Specific Antigen antibody

STJ16100172 St John's Laboratory 100 µg
EUR 466.8

anti- Cytokeratin 17-Specific antibody

FNab02203 FN Test 100µg
EUR 606.3
Description: Antibody raised against Cytokeratin 17-Specific

anti- Cytokeratin 19-specific antibody

FNab02210 FN Test 100µg
EUR 702
Description: Antibody raised against Cytokeratin 19-specific

Anti-Prostate Specific Antigen antibody

STJ16100961 St John's Laboratory 1 mL
EUR 577.2

Anti-Cytokeratin 1-specific antibody

PAab02211 Lifescience Market 100 ug
EUR 463.2

Anti-Cytokeratin 7-specific antibody

PAab02219 Lifescience Market 100 ug
EUR 463.2

Anti-Cytokeratin 7-specific antibody

PAab02220 Lifescience Market 100 ug
EUR 494.4

anti- TGF-beta 2-Specific antibody

FNab08639 FN Test 100µg
EUR 658.5
Description: Antibody raised against TGF-beta 2-Specific

anti- Thrombospondin 3-Specific antibody

FNab08675 FN Test 100µg
EUR 658.5
Description: Antibody raised against Thrombospondin 3-Specific

Anti-Cytokeratin 13-Specific antibody

PAab02194 Lifescience Market 100 ug
EUR 426

Anti-Cytokeratin 17-Specific antibody

PAab02203 Lifescience Market 100 ug
EUR 426

Anti-Cytokeratin 19-specific antibody

PAab02210 Lifescience Market 100 ug
EUR 494.4

Anti-Hepatocyte Specific Antigen antibody

STJ16100376 St John's Laboratory 1 mL
EUR 954

Anti-TGF-beta 2-Specific antibody

PAab08639 Lifescience Market 100 ug
EUR 463.2

Anti-Thrombospondin 3-Specific antibody

PAab08675 Lifescience Market 100 ug
EUR 463.2

anti- smooth muscle actin specific antibody

FNab08038 FN Test 100µg
EUR 606.3
Description: Antibody raised against smooth muscle actin specific

Kv1.4-Specific Antibody

abx234664-100ug Abbexa 100 ug
EUR 577.2

Mouse anti Human IgG (Fc Specific) antibody

10R-1908 Fitzgerald 100 ul
EUR 483.6
Description: Mouse anti Human IgG Fc fragment antibody

Mouse anti Human IgG (Fc Specific) antibody

10R-2045 Fitzgerald 100 ul
EUR 483.6
Description: Mouse anti Human IgG Fc fragment antibody

Anti-smooth muscle actin specific antibody

PAab08038 Lifescience Market 100 ug
EUR 426

Anti-Prostate Specific Antigen/KLK3 Antibody

PB9259 BosterBio 100ug/vial
EUR 352.8

Ldlrad3 3'UTR GFP Stable Cell Line

TU160981 ABM 1.0 ml Ask for price

LDLRAD3 3'UTR GFP Stable Cell Line

TU062366 ABM 1.0 ml
EUR 1825.2

Ldlrad3 3'UTR GFP Stable Cell Line

TU257001 ABM 1.0 ml Ask for price

TUBB3 specific antibody

PAab09890 Lifescience Market 100 ug
EUR 463.2

Ldlrad3 sgRNA CRISPR Lentivector set (Mouse)

K4550401 ABM 3 x 1.0 ug
EUR 406.8

LDLRAD3 sgRNA CRISPR Lentivector set (Human)

K1206201 ABM 3 x 1.0 ug
EUR 406.8

Rat Anti Calmodulin specific antibody ELISA kit

E02C0681-192T BlueGene 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Anti Calmodulin specific antibody ELISA kit

E02C0681-48 BlueGene 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Anti Calmodulin specific antibody ELISA kit

E02C0681-96 BlueGene 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Anti Calmodulin specific antibody ELISA kit

E08C0681-192T BlueGene 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Anti Calmodulin specific antibody ELISA kit

E08C0681-48 BlueGene 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Anti Calmodulin specific antibody ELISA kit

E08C0681-96 BlueGene 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Anti Calmodulin specific antibody ELISA kit

E07C0681-192T BlueGene 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Anti Calmodulin specific antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
×

p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).

 

In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.

 

Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice

 

 

STAT3 antibody

10R-2269 Fitzgerald 100 ul
EUR 483.6
Description: Mouse monoclonal STAT3 antibody

STAT3 antibody

10R-5956 Fitzgerald 100 ul
EUR 871.2
Description: Mouse monoclonal STAT3 antibody

Stat3 antibody

20R-1593 Fitzgerald 100 ug
EUR 807.6
Description: Rabbit polyclonal Stat3 antibody

Stat3 antibody

20R-1597 Fitzgerald 100 ug
EUR 846
Description: Rabbit polyclonal Stat3 antibody

STAT3 antibody

20R-1911 Fitzgerald 50 ug
EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

20R-1912 Fitzgerald 50 ug
EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

20R-2227 Fitzgerald 50 ug
EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

20R-2228 Fitzgerald 50 ug
EUR 337.2
Description: Rabbit polyclonal STAT3 antibody

STAT3 Antibody

43315-100ul SAB 100ul
EUR 302.4

STAT3 Antibody

7197-002mg ProSci 0.02 mg
EUR 206.18
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

STAT3 Antibody

7197-01mg ProSci 0.1 mg
EUR 523.7
Description: STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

STAT3 Antibody

BF0354 Affbiotech 200ul
EUR 540

STAT3 Antibody

AF5205 Affbiotech 200ul
EUR 420

STAT3 Antibody

AF6293 Affbiotech 200ul
EUR 420

STAT3 Antibody

AF6294 Affbiotech 200ul
EUR 420

STAT3 Antibody

AF6295 Affbiotech 200ul
EUR 420

STAT3 antibody

70R-11848 Fitzgerald 100 ug
EUR 483.6
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-13773 Fitzgerald 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-14315 Fitzgerald 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-31708 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-32513 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-32515 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-20573 Fitzgerald 50 ul
EUR 522
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody

70R-37485 Fitzgerald 100 ug
EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody

70R-37486 Fitzgerald 100 ug
EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody

70R-51642 Fitzgerald 100 ul
EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-50431 Fitzgerald 100 ul
EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-50432 Fitzgerald 100 ul
EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-50433 Fitzgerald 100 ul
EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody

70R-35948 Fitzgerald 100 ug
EUR 418.8
Description: Rabbit polyclonal STAT3 antibody

Stat3 Antibody

3470R-100 Biovision each
EUR 379.2

Stat3 Antibody

3470R-30T Biovision each
EUR 175.2

STAT3 Antibody

48732-100ul SAB 100ul
EUR 399.6

STAT3 Antibody

48732-50ul SAB 50ul
EUR 286.8

Stat3 Antibody

48780-100ul SAB 100ul
EUR 399.6

Stat3 Antibody

48780-50ul SAB 50ul
EUR 286.8

STAT3 Antibody

ABF5205 Lifescience Market 100 ug
EUR 525.6

STAT3 Antibody

ABF6293 Lifescience Market 100 ug
EUR 525.6

STAT3 Antibody

ABF6294 Lifescience Market 100 ug
EUR 525.6

STAT3 Antibody

ABF6295 Lifescience Market 100 ug
EUR 525.6

STAT3 Antibody

1-CSB-PA050164 Cusabio
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

STAT3 Antibody

1-CSB-PA004173 Cusabio
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

STAT3 Antibody

1-CSB-PA004174 Cusabio
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

STAT3 Antibody

1-CSB-PA080245 Cusabio
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

STAT3 Antibody

1-CSB-PA022812GA01HU Cusabio
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

STAT3 Antibody

1-CSB-PA022812LA01HU Cusabio
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against STAT3. Recognizes STAT3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000

STAT3 Antibody

F52106-0.08ML NSJ Bioreagents 0.08 ml
EUR 140.25
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody

F52106-0.4ML NSJ Bioreagents 0.4 ml
EUR 322.15
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody

F52120-0.08ML NSJ Bioreagents 0.08 ml
EUR 140.25
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody

F52120-0.4ML NSJ Bioreagents 0.4 ml
EUR 322.15
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

STAT3 Antibody

F52478-0.08ML NSJ Bioreagents 0.08 ml
EUR 140.25
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

STAT3 Antibody

F52478-0.4ML NSJ Bioreagents 0.4 ml
EUR 330.65
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

STAT3 Antibody

F46167-0.08ML NSJ Bioreagents 0.08 ml
EUR 140.25
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 Antibody

F47582-0.08ML NSJ Bioreagents 0.08 ml
EUR 140.25
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 Antibody

F47582-0.4ML NSJ Bioreagents 0.4 ml
EUR 322.15
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 Antibody

R32089 NSJ Bioreagents 100 ug
EUR 356.15
Description: The transcription factor, signal transducer and activator of transcription-3 (STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21. It contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.

STAT3 Antibody

R33329-100UG NSJ Bioreagents 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Signal transducer and activator of transcription 3

STAT3 Antibody

R33548-100UG NSJ Bioreagents 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Signal transducer and activator of transcription 3

STAT3 Antibody

V3921-100UG NSJ Bioreagents 100 ug
EUR 349.3
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

STAT3 Antibody

V3921-20UG NSJ Bioreagents 20 ug
EUR 153.3
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

STAT3 Antibody

V3921SAF-100UG NSJ Bioreagents 100 ug
EUR 349.3
Description: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

STAT3 antibody (Ser727)

70R-32512 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody (Ser727)

STAT3 antibody (Tyr705)

70R-32514 Fitzgerald 100 ug
EUR 392.4
Description: Rabbit polyclonal STAT3 antibody (Tyr705)

STAT3 antibody (Tyr705)

70R-37126 Fitzgerald 100 ug
EUR 418.8
Description: Rabbit Polyclonal STAT3 antibody (Tyr705)

STAT3 antibody (Ser727)

70R-37127 Fitzgerald 100 ug
EUR 418.8
Description: Rabbit Polyclonal STAT3 antibody (Ser727)

Phospho STAT3 antibody

20R-2918 Fitzgerald 100 ul
EUR 471.6
Description: Rabbit polyclonal Phospho STAT3 antibody

STAT3 Antibody (pTyr705)

R20279-0.1ML NSJ Bioreagents 100ul
EUR 347.65
Description: This recombinant phospho-Stat3 antibody reacts to human Stat3 only when phosphorylated at Tyr705. There is no cross-reactivity to Stat3 without phosphorylation at Tyr705. It may also react to mouse or rat phospho-Stat3 (Tyr705), as predicted by immunogen homology.

Polyclonal STAT3 Antibody

APR11195G Leading Biology 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human STAT3 . This antibody is tested and proven to work in the following applications:

Polyclonal Stat3 Antibody

APR11196G Leading Biology 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Stat3 . This antibody is tested and proven to work in the following applications:

Monoclonal STAT3 Antibody

APR11197G Leading Biology 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human STAT3. The antibodies are raised in Mouse. This antibody is applicable in WB

Monoclonal Stat3 antibody

APR17866G Leading Biology 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Stat3. The antibodies are raised in Mouse. This antibody is applicable in WB

Monoclonal STAT3 Antibody

APR17867G Leading Biology 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human STAT3. The antibodies are raised in Mouse. This antibody is applicable in WB

Recombinant STAT3 Antibody

R20477-0.1ML NSJ Bioreagents 100ul
EUR 409

STAT3 (AcK87) Antibody

20-abx141170 Abbexa
  • EUR 460.80
  • EUR 727.20
  • EUR 276.00
  • 100 ul
  • 200 ul
  • 30 ul

STAT3 (pY705) Antibody

20-abx133878 Abbexa
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

STAT3 (pS727) Antibody

20-abx119323 Abbexa
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

STAT3 (pS727) Antibody

abx031919-400ul Abbexa 400 ul
EUR 627.6

STAT3 (pS727) Antibody

abx031919-80l Abbexa 80 µl
EUR 343.2

STAT3 (pY705) Antibody

abx031920-400ul Abbexa 400 ul
EUR 627.6

STAT3 (pY705) Antibody

abx031920-80l Abbexa 80 µl
EUR 343.2

Stat3 (pY705) Antibody

20-abx000144 Abbexa
  • EUR 594.00
  • EUR 844.80
  • EUR 260.40
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

STAT3 (pS727) Antibody

20-abx000188 Abbexa
  • EUR 594.00
  • EUR 844.80
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 50 ul

STAT3 (pS727) Antibody

20-abx009767 Abbexa
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

STAT3 (pY705) Antibody

abx011825-100ug Abbexa 100 ug
EUR 526.8
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