Purification of a fraction of MDM2 for manufacturing of polyclonal antisera.

A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni–NTA chromatography and preparative gel electrophoresis. The purified MDM2 fragment was used to generate polyclonal antisera that acknowledge a number of species of MDM2 proteins, together with the inhibitor of p53, p90(MDM2), in addition to the activator of p53, p76(MDM2). The antibodies are helpful for Western evaluation, immunoprecipitation, and immunofluorescence.

 

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus.

Introduction. Systemic lupus erythematosus (SLE) is without doubt one of the systemic autoimmune illnesses characterised by the polyclonal autoantibody manufacturing. The human homologue of the mouse double minute 2 (MDM2) is effectively often called the detrimental regulator of p53. MDM2 has been reported to be overexpressed in SLE animal mannequin and to advertise SLE.

Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE sufferers. Strategies. Anti-MDM2 antibody in sera from 43 SLE sufferers and 69 wholesome individuals was investigated by ELISA. Constructive samples had been additional confirmed by western blotting.

 

The immunological feathers of anti-MDM2 constructive sera had been analyzed by oblique immunofluorescence assay. Anti-p53 was additionally investigated in SLE sufferers by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed. Outcomes.

 

The presence of anti-MDM2 in SLE sufferers was 23.30%, a lot larger than regular wholesome individuals (4.30%). These anti-MDM2 constructive sera current a nuclear staining sample. The presence of anti-p53 in SLE sufferers was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE sufferers. Conclusions. Anti-MDM2 autoantibody was detected at excessive prevalence in SLE sufferers. The detection of anti-MDM2 in SLE sufferers must be clinically helpful.

 

 

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Systemic lupus erythematosus (SLE) is a polyclonal autoimmune syndrome directed towards a number of nuclear autoantigens. Though RNA and DNA appear to have equivalent immunostimulatory results on systemic and intrarenal irritation, every appears to vary with regard to the propensity to induce mitogenic results resembling lymphoproliferation.

To establish potential mechanisms by which DNA particularly contributes to the pathogenesis of lupus nephritis, we stimulated cells with immunostimulatory DNA or RNA in vitro and used microarray to match the transcriptomes of RNA- and DNA-induced genes. Immunostimulatory DNA, however not RNA, induced Mdm2, which is a detrimental regulator of p53. In vivo, we noticed better expression and activation of Mdm2 within the spleen and kidneys in a mouse mannequin of lupus (MRL-Fas(lpr) mice) than wholesome controls.

 

Therapy of MRL-Fas(lpr) mice with the Mdm2 inhibitor nutlin-3a prevented nephritis and lung illness and considerably extended survival. Inhibition of Mdm2 lowered systemic irritation and abrogated immune complicated illness by suppressing plasma cells and the manufacturing of lupus autoantibodies. As well as, nutlin-3a suppressed the irregular growth of all T cell subsets, together with CD3(+)CD4(-)CD8(-) T cells, which related to attenuated systemic irritation.

 

Nevertheless, inhibiting Mdm2 didn’t trigger myelosuppression or have an effect on splenic regulatory T cells, neutrophils, dendritic cells, or monocytes. Taken collectively, these information recommend that the induction of Mdm2 promotes the growth of plasma cells and CD3(+)CD4(-)CD8(-) T cells, which trigger autoantibody manufacturing and immune complicated illness in MRL-Fas(lpr) mice. Antagonizing Mdm2 might have therapeutic potential in lupus nephritis.

LDLRAD3 Antibody
CSB-PA786511-	Cusabio		EUR 402
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

LDLRAD3 Antibody
CSB-PA786511-100ul	Cusabio	100ul	EUR 379.2
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

LDLRAD3 Antibody
1-CSB-PA007326	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 418.8

LDLRAD3 Polyclonal Antibody
ABP53840-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Polyclonal Antibody
ABP53840-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90

LDLRAD3 Conjugated Antibody
C34765	SAB	100ul	EUR 476.4

LDLRAD3 Polyclonal Antibody
ES4839-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 Polyclonal Antibody
ES4839-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA

LDLRAD3 siRNA
20-abx922395	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

LDLRAD3 siRNA
20-abx922396	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

LDLRAD3 Blocking Peptide
33R-1897	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224

LDLRAD3 Blocking Peptide
20-abx162318	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

LDLRAD3 cloning plasmid
CSB-CL803154HU-10ug	Cusabio	10ug	EUR 481.2
Description: A cloning plasmid for the LDLRAD3 gene.

Polyclonal LDLRAD3 antibody - middle region
APR01194G	Leading Biology	0.05mg	EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications:

Human LDLRAD3 shRNA Plasmid
20-abx965371	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Mouse LDLRAD3 shRNA Plasmid
20-abx982528	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human LDLRAD3 ELISA KIT
ELI-39778h	Lifescience Market	96 Tests	EUR 988.8

Mouse Ldlrad3 ELISA KIT
ELI-27814m	Lifescience Market	96 Tests	EUR 1038

LDLRAD3 Recombinant Protein (Human)
RP040687	ABM	100 ug	Ask for price

LDLRAD3 Recombinant Protein (Mouse)
RP147182	ABM	100 ug	Ask for price

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 336

Anti-ACADL-Specific antibody
PAab00064	Lifescience Market	100 ug	EUR 426

Anti-ACTA1-Specific antibody
PAab00115	Lifescience Market	100 ug	EUR 426

Anti-ADAM17-Specific antibody
PAab00139	Lifescience Market	100 ug	EUR 426

Anti-ADRA1A-Specific antibody
PAab00177	Lifescience Market	100 ug	EUR 426

Anti-ADRA2B-Specific antibody
PAab00179	Lifescience Market	100 ug	EUR 463.2

Anti-AFF1-Specific antibody
PAab00195	Lifescience Market	100 ug	EUR 426

Anti-AKAP11-Specific antibody
PAab00251	Lifescience Market	100 ug	EUR 426

Anti-AMPD1-Specific antibody
PAab00370	Lifescience Market	100 ug	EUR 463.2

Anti-ARF5-Specific antibody
PAab00534	Lifescience Market	100 ug	EUR 426

Anti-ARF6-Specific antibody
PAab00535	Lifescience Market	100 ug	EUR 426

Anti-ARHGEF9-Specific antibody
PAab00565	Lifescience Market	100 ug	EUR 426

Anti-ARSK-Specific antibody
PAab00613	Lifescience Market	100 ug	EUR 426

Anti-ATF2-Specific antibody
PAab00661	Lifescience Market	100 ug	EUR 426

Anti-ATP1A1-Specific antibody
PAab00692	Lifescience Market	100 ug	EUR 463.2

Anti-ATP1A2-Specific antibody
PAab00694	Lifescience Market	100 ug	EUR 463.2

Anti-ATP5G2-Specific antibody
PAab00708	Lifescience Market	100 ug	EUR 426

Anti-BAG1S-specific antibody
PAab00788	Lifescience Market	100 ug	EUR 463.2

Anti-BAI2-Specific antibody
PAab00791	Lifescience Market	100 ug	EUR 426

Anti-BAI3-Specific antibody
PAab00792	Lifescience Market	100 ug	EUR 426

Anti-Barkor-Specific antibody
PAab00806	Lifescience Market	100 ug	EUR 426

Anti-BLOC1S1-Specific antibody
PAab00909	Lifescience Market	100 ug	EUR 426

Anti-BRN2-Specific antibody
PAab00963	Lifescience Market	100 ug	EUR 426

Anti-BTF3L3-Specific antibody
PAab00976	Lifescience Market	100 ug	EUR 426

Anti-SLC12A5-Specific antibody
PAab07908	Lifescience Market	100 ug	EUR 463.2

Anti-SLC25A6-Specific antibody
PAab07947	Lifescience Market	100 ug	EUR 463.2

Anti-SLIT2-Specific antibody
PAab07981	Lifescience Market	100 ug	EUR 463.2

Anti-SMYD1-Specific antibody
PAab08047	Lifescience Market	100 ug	EUR 463.2

Anti-Somatostatin-Specific antibody
PAab08109	Lifescience Market	100 ug	EUR 463.2

Anti-SPAG4-Specific antibody
PAab08142	Lifescience Market	100 ug	EUR 463.2

Anti-SPIN1-Specific antibody
PAab08178	Lifescience Market	100 ug	EUR 494.4

Anti-SPTBN1-Specific antibody
PAab08204	Lifescience Market	100 ug	EUR 463.2

Anti-SRGAP3-Specific antibody
PAab08227	Lifescience Market	100 ug	EUR 463.2

Anti-ST8SIA2-Specific antibody
PAab08276	Lifescience Market	100 ug	EUR 463.2

Anti-STEAP2-Specific antibody
PAab08317	Lifescience Market	100 ug	EUR 463.2

Anti-SURVIVIN-Specific antibody
PAab08403	Lifescience Market	100 ug	EUR 426

Anti-SYN1-Specific antibody
PAab08416	Lifescience Market	100 ug	EUR 463.2

Anti-TAF1-Specific antibody
PAab08484	Lifescience Market	100 ug	EUR 494.4

Anti-TDRKH specific antibody
PAab08580	Lifescience Market	100 ug	EUR 463.2

Anti-TGFBR3-Specific antibody
PAab08645	Lifescience Market	100 ug	EUR 494.4

Anti-TINAG-Specific antibody
PAab08712	Lifescience Market	100 ug	EUR 494.4

Anti-TMF1-Specific antibody
PAab08796	Lifescience Market	100 ug	EUR 494.4

Anti-TOP2A-Specific antibody
PAab08868	Lifescience Market	100 ug	EUR 494.4

Anti-Tuberin-Specific antibody
PAab09101	Lifescience Market	100 ug	EUR 463.2

Anti-TWIST1-specific antibody
PAab09118	Lifescience Market	100 ug	EUR 494.4

Anti-UBASH3A-Specific antibody
PAab09150	Lifescience Market	100 ug	EUR 463.2

Anti-UBC9-Specific antibody
PAab09159	Lifescience Market	100 ug	EUR 463.2

Anti-UBE2D1-Specific antibody
PAab09167	Lifescience Market	100 ug	EUR 463.2

Anti-UBN1-Specific antibody
PAab09202	Lifescience Market	100 ug	EUR 463.2

Anti-UNC5C-Specific antibody
PAab09263	Lifescience Market	100 ug	EUR 463.2

Anti-UNC5D-Specific antibody
PAab09264	Lifescience Market	100 ug	EUR 494.4

Anti-URB1-Specific antibody
PAab09286	Lifescience Market	100 ug	EUR 494.4

Anti-WASF4-Specific antibody
PAab09469	Lifescience Market	100 ug	EUR 494.4

Anti-YES1-Specific antibody
PAab09563	Lifescience Market	100 ug	EUR 463.2

Anti-ZIC4-Specific antibody
PAab09637	Lifescience Market	100 ug	EUR 494.4

Anti-ZNF600-Specific antibody
PAab09718	Lifescience Market	100 ug	EUR 494.4

Anti-ZNRF2-Specific antibody
PAab09746	Lifescience Market	100 ug	EUR 463.2

Anti-CAPG-Specific antibody
PAab01249	Lifescience Market	100 ug	EUR 426

Anti-Catalase-Specific antibody
PAab01302	Lifescience Market	100 ug	EUR 426

Anti-CCKAR-specific antibody
PAab01377	Lifescience Market	100 ug	EUR 426

Anti-CCKBR-specific antibody
PAab01378	Lifescience Market	100 ug	EUR 426

Anti-CCR2-specific antibody
PAab01390	Lifescience Market	100 ug	EUR 426

Anti-CCT6A-Specific antibody
PAab01401	Lifescience Market	100 ug	EUR 426

p53 standing dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

The proapoptotic perform of p53 is assumed to underlie most anticancer modalities and can be activated in response to oncogenic insults, resembling overexpression of the Myc oncoprotein. Right here we generated tractable B lymphomas utilizing retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)).

 

In these polyclonal tumors, Myc is the one oncogenic lesion, and p53ER(TAM) standing will be quickly toggled between “off” and “on” with 4OHT, supplied that the Trp53 promoter has been independently activated. Though 4OHT can set off widespread apoptosis and overt tumor regression even within the absence of DNA-damaging brokers, in tumors with excessive ranges of Mdm2 these responses are blunted.

 

Nevertheless, cotreatment with proteasome inhibitors absolutely restores therapeutic results in vivo. Equally, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are extremely delicate to proteasome inhibitors, except p53 ranges are lowered utilizing the HPV-E6 ubiquitin ligase. Due to this fact, proteasome inhibitors could possibly be extremely efficient as a monotherapy towards Myc-induced lymphomas, without having for adjuvant chemotherapy or radiation remedy. Then again, their efficacy is crucially depending on the wild-type p53 standing of the tumor, putting vital restrictions on affected person choice

 

 

anti- STAT3 antibody
FNab08300	FN Test	100µg	EUR 658.5
Description: Antibody raised against STAT3

Anti-STAT3 Antibody
PA1108	BosterBio	100ug/vial	EUR 400.8

Anti-STAT3 Antibody
PA1778	BosterBio	100ug/vial	EUR 400.8

Anti-STAT3 Antibody
PB9511	BosterBio	100ug/vial	EUR 352.8

Anti-STAT3 antibody
STJ113436	St John's Laboratory	50 µl	EUR 344.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ113737	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ118189	St John's Laboratory	100 µl	EUR 332.4

Anti-STAT3 antibody
STJ119281	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Stat3 antibody
STJ98399	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Stat3.

Anti-Stat3 antibody
STJ98400	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Stat3.

Anti-STAT3 antibody
STJ99212	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to STAT3.

Anti-Stat3 antibody
STJ95808	St John's Laboratory	200 µl	EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ95808 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Stat3 protein.

Anti-Stat3 antibody
STJ95809	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ95810	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ97467	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-Stat3 antibody
STJ97468	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3.

Anti-STAT3 antibody
STJ97520	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to STAT3 (1E3).

Anti-STAT3 antibody
STJ97525	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to STAT3 (3F4).

Anti-STAT3 antibody
STJ29841	St John's Laboratory	100 µl	EUR 495.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 antibody
STJ27462	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-STAT3 Antibody
STJ503137	St John's Laboratory	100 µg	EUR 571.2

Anti-STAT3 antibody
STJ70982	St John's Laboratory	100 µg	EUR 430.8

anti-STAT3
YF-PA14814	Abfrontier	50 ug	EUR 435.6
Description: Mouse polyclonal to STAT3

Anti-Phospho-STAT3 Antibody
STJ502696	St John's Laboratory	100 µg	EUR 703.2

Anti-STAT3 Antibody (Biotin)
STJ503138	St John's Laboratory	100 µg	EUR 703.2

Anti-STAT3 Antibody (FITC)
STJ503139	St John's Laboratory	100 µg	EUR 703.2

anti-STAT3 (3B5)
LF-MA30485	Abfrontier	100 ul	EUR 583.2
Description: Mouse Monoclonal to STAT3

anti-STAT3 (7G3H4)
LF-MA30243	Abfrontier	100 ul	EUR 583.2
Description: Mouse Monoclonal to STAT3

Anti-STAT3 (4D6)
YF-MA10886	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to STAT3

Polyclonal Goat Anti-STAT3 Antibody
APG00319G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STAT3 . This antibody is tested and proven to work in the following applications:

Anti-STAT3 Rabbit Monoclonal Antibody
M00007	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody
M00007-1	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-STAT3 Rabbit Monoclonal Antibody
M00007-2	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal STAT3 Antibody. Validated in IP, IF, WB and tested in Human.

Anti-Phospho-STAT3-(S727) antibody
STJ116371	St John's Laboratory	100 µl	EUR 471.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Stat3 (Acetyl Lys87) antibody
STJ97699	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Stat3 (Acetyl Lys87).

Anti-Phospho-Stat3 (Y705) antibody
STJ97747	St John's Laboratory	200 µl	EUR 236.4
Description: Mouse monoclonal to Phospho-Stat3 (Y705).

Anti-Phospho-STAT3-(Y705) antibody
STJ27511	St John's Laboratory	100 µl	EUR 471.6
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-Phospho-Stat3 (S727) antibody
STJ90410	St John's Laboratory	200 µl	EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90410 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about S727 when S727 is phosphorylated.

Anti-Phospho-Stat3 (Y705) antibody
STJ90411	St John's Laboratory	200 µl	EUR 236.4
Description: Stat3 is a protein encoded by the STAT3 gene which is approximately 88 kDa. Stat3 is localised to the cytoplasm and nucleus. It is involved in the immune response IL-23 signalling pathway, RET signalling, Th17 cell differentiation and prolactin signalling pathway. This protein falls under the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Stat3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in the STAT3 gene may result in Hyperimmunoglobulin E recurrent infection syndrome. STJ90411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Stat3 protein which only binds about Y705 when Y705 is phosphorylated.

Anti-Phospho-STAT3 Antibody BIOTIN
STJ502697	St John's Laboratory	100 µg	EUR 774

Anti-Phospho-STAT3 Antibody FITC
STJ502698	St John's Laboratory	100 µg	EUR 774

Anti-Stat3 (Acetyl-Lys49) Antibody
STJ193228	St John's Laboratory	200 µl	EUR 236.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Hu-48T	DL Develop	48T	EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Hu-96T	DL Develop	96T	EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Mu-48T	DL Develop	48T	EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Mu-96T	DL Develop	96T	EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Ra-48T	DL Develop	48T	EUR 633.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
DLR-STAT3-Ra-96T	DL Develop	96T	EUR 828
Description: A sandwich quantitative ELISA assay kit for detection of Rat Signal Transducer And Activator Of Transcription 3 (STAT3) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Hu-48Tests	Reddot Biotech	48 Tests	EUR 600

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Hu-96Tests	Reddot Biotech	96 Tests	EUR 830.4

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Mu-48Tests	Reddot Biotech	48 Tests	EUR 613.2

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Mu-96Tests	Reddot Biotech	96 Tests	EUR 850.8

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Ra-48Tests	Reddot Biotech	48 Tests	EUR 640.8

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RD-STAT3-Ra-96Tests	Reddot Biotech	96 Tests	EUR 890.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Hu-48Tests	Reddot Biotech	48 Tests	EUR 626.4

Human Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Hu-96Tests	Reddot Biotech	96 Tests	EUR 868.8

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Mu-48Tests	Reddot Biotech	48 Tests	EUR 640.8

Mouse Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Mu-96Tests	Reddot Biotech	96 Tests	EUR 890.4

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Ra-48Tests	Reddot Biotech	48 Tests	EUR 669.6

Rat Signal Transducer And Activator Of Transcription 3 (STAT3) ELISA Kit
RDR-STAT3-Ra-96Tests	Reddot Biotech	96 Tests	EUR 931.2

STAT3 antibody
70R-11848	Fitzgerald	100 ug	EUR 483.6
Description: Rabbit polyclonal STAT3 antibody

STAT3 Antibody
43315-100ul	SAB	100ul	EUR 302.4

STAT3 antibody
70R-37485	Fitzgerald	100 ug	EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody
70R-37486	Fitzgerald	100 ug	EUR 327.6
Description: Rabbit Polyclonal STAT3 antibody

STAT3 antibody
70R-50431	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50432	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-50433	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-20573	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-35948	Fitzgerald	100 ug	EUR 418.8
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-31708	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-32513	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-32515	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-14315	Fitzgerald	100 ug	EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 antibody
70R-51642	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal STAT3 antibody

STAT3 antibody
70R-13773	Fitzgerald	100 ug	EUR 386.4
Description: Affinity purified Rabbit polyclonal STAT3 antibody

STAT3 Antibody
48732-100ul	SAB	100ul	EUR 399.6

STAT3 Antibody
48732-50ul	SAB	50ul	EUR 286.8

Stat3 Antibody
48780-100ul	SAB	100ul	EUR 399.6

Stat3 Antibody
48780-50ul	SAB	50ul	EUR 286.8

Stat3 Antibody
3470R-100	Biovision		EUR 379.2

Stat3 Antibody
3470R-30T	Biovision		EUR 175.2

STAT3 antibody
10R-5956	Fitzgerald	100 ul	EUR 871.2
Description: Mouse monoclonal STAT3 antibody

STAT3 antibody
10R-1224	Fitzgerald	100 ug	EUR 614.4
Description: Mouse monoclonal STAT3 antibody

Stat3 antibody
20R-1593	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Stat3 antibody